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Detection of Group B Streptococcus in pregnancy by vaginal volatile organic compound analysis : a prospective exploratory study
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Lacey, Lauren, Daulton, Emma, Wicaksono, Alfian, Covington, James A. and Quenby, Siobhan (2019) Detection of Group B Streptococcus in pregnancy by vaginal volatile organic compound analysis : a prospective exploratory study. Translational Research . doi:10.1016/j.trsl.2019.09.002 (In Press)
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WRAP-Detection-Group-B-Streptococcus-pregnancy-vaginal-study-Covington-2019.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (623Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.trsl.2019.09.002
Abstract
Our objective was to assess whether volatile organic compound (VOC) analysis of vaginal swabs can detect maternal Group B Streptococcus (GBS) during pregnancy in a prospective exploratory study. Around 243 women attending a high-risk antenatal clinic at one university teaching hospital in the UK consented to take part and provide vaginal swabs throughout pregnancy. VOC analysis of vaginal swabs was undertaken and compared with the reference standard of GBS detected using enrichment culture method. The chemical components that emanated from the vaginal swabs were measured by gas chromatograph ion mobility spectrometry. This platform has both high sensitivity and good specificity to a range of chemical compounds. Our main outcome was to determine the sensitivity and specificity of VOC analysis for the detection of maternal GBS in vaginal swabs during pregnancy. Our study has demonstrated that the sensitivity and specificity of the VOC analysis by GC–IMS for the detection of GBS from vaginal swabs was 0.81 (95% confidence interval [CI], 0.71–0.89) and 0.97 (95% CI, 0.91–1) respectively. We conclude that the use of VOCs as biomarkers for the detection of maternal GBS in the vagina is a novel tool. As this test produces results within minutes and is of low unit test cost it has the potential to be used in clinical settings, where fast diagnosis is important, for example, a patient in early labour.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology Q Science > QR Microbiology R Medicine > RG Gynecology and obstetrics |
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| Divisions: | Faculty of Science > Engineering Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Streptococcus agalactiae, Streptococcus agalactiae -- Prevention, Prenatal care, Communicable diseases in pregnancy, Neonatal infections -- Prevention, Pregnancy -- Complications, Volatile organic compounds , Volatile organic compounds, Gas chromatography , Ion mobility spectroscopy | ||||||
| Journal or Publication Title: | Translational Research | ||||||
| Publisher: | Elsevier Inc. | ||||||
| ISSN: | 1931-5244 | ||||||
| Official Date: | 18 September 2019 | ||||||
| Dates: |
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| Date of first compliant deposit: | 1 October 2019 | ||||||
| DOI: | 10.1016/j.trsl.2019.09.002 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | In Press | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| RIOXX Funder/Project Grant: |
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