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Detection of Group B Streptococcus in pregnancy by vaginal volatile organic compound analysis : a prospective exploratory study

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Lacey, Lauren, Daulton, Emma, Wicaksono, Alfian, Covington, James A. and Quenby, Siobhan (2020) Detection of Group B Streptococcus in pregnancy by vaginal volatile organic compound analysis : a prospective exploratory study. Translational Research, 216 . pp. 23-29. doi:10.1016/j.trsl.2019.09.002 ISSN 1931-5244.

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Official URL: http://dx.doi.org/10.1016/j.trsl.2019.09.002

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Abstract

Our objective was to assess whether volatile organic compound (VOC) analysis of vaginal swabs can detect maternal Group B Streptococcus (GBS) during pregnancy in a prospective exploratory study. Around 243 women attending a high-risk antenatal clinic at one university teaching hospital in the UK consented to take part and provide vaginal swabs throughout pregnancy. VOC analysis of vaginal swabs was undertaken and compared with the reference standard of GBS detected using enrichment culture method. The chemical components that emanated from the vaginal swabs were measured by gas chromatograph ion mobility spectrometry. This platform has both high sensitivity and good specificity to a range of chemical compounds. Our main outcome was to determine the sensitivity and specificity of VOC analysis for the detection of maternal GBS in vaginal swabs during pregnancy. Our study has demonstrated that the sensitivity and specificity of the VOC analysis by GC–IMS for the detection of GBS from vaginal swabs was 0.81 (95% confidence interval [CI], 0.71–0.89) and 0.97 (95% CI, 0.91–1) respectively. We conclude that the use of VOCs as biomarkers for the detection of maternal GBS in the vagina is a novel tool. As this test produces results within minutes and is of low unit test cost it has the potential to be used in clinical settings, where fast diagnosis is important, for example, a patient in early labour.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
Q Science > QR Microbiology
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Streptococcus agalactiae, Streptococcus agalactiae -- Prevention, Prenatal care, Communicable diseases in pregnancy, Neonatal infections -- Prevention, Pregnancy -- Complications, Volatile organic compounds , Volatile organic compounds, Gas chromatography , Ion mobility spectroscopy
Journal or Publication Title: Translational Research
Publisher: Elsevier Inc.
ISSN: 1931-5244
Official Date: 1 February 2020
Dates:
DateEvent
1 February 2020Published
18 September 2019Available
9 September 2019Accepted
Volume: 216
Page Range: pp. 23-29
DOI: 10.1016/j.trsl.2019.09.002
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 1 October 2019
Date of first compliant Open Access: 18 September 2020
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDRosetrees Trusthttp://dx.doi.org/10.13039/501100000833

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