Palmer, Tracy and Stansfeld, Phillip J. (2020) Targeting of proteins to the twin-arginine transport pathway. Molecular Microbiology, 113 (5). pp. 861-871. doi:10.1111/mmi.14461 ISSN 0950-382X.
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Abstract
The twin-arginine protein transport (Tat pathway) is found in prokaryotes and plant organelles and transports folded proteins across membranes. Targeting of substrates to the Tat system is mediated by the presence of an N-terminal signal sequence containing a highly conserved twin-arginine motif. The Tat machinery comprises membrane proteins from the TatA and TatC families. Assembly of the Tat translocon is dynamic and is triggered by the interaction of a Tat substrate with the Tat receptor complex. This review will summarise recent advances in our understanding of Tat transport, focusing in particular on the roles played by Tat signal peptides in protein targeting and translocation. [Abstract copyright: © 2020 John Wiley & Sons Ltd.]
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
| SWORD Depositor: | Library Publications Router |
| Library of Congress Subject Headings (LCSH): | Proteins -- Physiological transport, Proteins -- Secretion, Protein binding |
| Journal or Publication Title: | Molecular Microbiology |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| ISSN: | 0950-382X |
| Official Date: | May 2020 |
| Dates: | Date Event May 2020 Published 23 January 2020 Available 11 January 2020 Accepted |
| Volume: | 113 |
| Number: | 5 |
| Page Range: | pp. 861-871 |
| DOI: | 10.1111/mmi.14461 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Re-use Statement: | "This is the peer reviewed version of the following article: Palmer, T. and Stansfeld, P.J. (2020), Targeting of proteins to the twin‐arginine transport pathway. Mol Microbiol. Accepted Author Manuscript which has been published in final form at https://doi.org/10.1111/mmi.14461. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." |
| Access rights to Published version: | Restricted or Subscription Access |
| Date of first compliant deposit: | 10 February 2020 |
| Date of first compliant Open Access: | 23 January 2021 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID EP/R029407/1 [EPSRC] Engineering and Physical Sciences Research Council |
| URI: | https://wrap.warwick.ac.uk/132929/ |
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