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Volatile organic compound analysis, a new tool in the quest for preterm birth prediction—an observational cohort study
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Lacey, Lauren, Daulton, Emma, Wicaksono, Alfian, Covington, James A. and Quenby, Siobhan (2020) Volatile organic compound analysis, a new tool in the quest for preterm birth prediction—an observational cohort study. Scientific Reports, 10 (1). 12153 . doi:10.1038/s41598-020-69142-4 ISSN 2045-2322.
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WRAP-Volatile-organic-compound-tool-preterm-birth-observational-cohort-Covington-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1000Kb) | Preview |
Official URL: https://doi.org/10.1038/s41598-020-69142-4
Abstract
Preterm birth is the leading cause of death worldwide in children under five years. Due to its complex multifactorial nature, prediction is a challenge. Current research is aiming to develop accurate predictive models using patient history, ultrasound and biochemical markers. Volatile organic compound (VOC) analysis is an approach, which has good diagnostic potential to predict many disease states. Analysis of VOCs can reflect both the microbiome and host response to a condition. We aimed to ascertain if VOC analysis of vaginal swabs, taken throughout pregnancy, could predict which women go on to deliver preterm. Our prospective observational cohort study demonstrates that VOC analysis of vaginal swabs, taken in the midtrimester, is a fair test (AUC 0.79) for preterm prediction, with a sensitivity of 0.66 (95%CI 0.56–0.75) and specificity 0.89 (95%CI 0.82–0.94). Using vaginal swabs taken closest to delivery, VOC analysis is a good test (AUC 0.84) for the prediction of preterm birth with a sensitivity of 0.73 (95%CI 0.64–0.81) and specificity of 0.90 (95%CI 0.82–0.95). Consequently, VOC analysis of vaginal swabs has potential to be used as a predictive tool. With further work it could be considered as an additional component in models for predicting preterm birth.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Premature labor, Premature labor -- Prevention, Volatile organic compounds, Volatile organic compounds -- Health aspects, Labor (Obstetrics) -- Complications | |||||||||
| Journal or Publication Title: | Scientific Reports | |||||||||
| Publisher: | Nature Publishing Group UK | |||||||||
| ISSN: | 2045-2322 | |||||||||
| Official Date: | 22 July 2020 | |||||||||
| Dates: |
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| Volume: | 10 | |||||||||
| Number: | 1 | |||||||||
| Article Number: | 12153 | |||||||||
| DOI: | 10.1038/s41598-020-69142-4 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 18 September 2020 | |||||||||
| Date of first compliant Open Access: | 21 September 2020 | |||||||||
| RIOXX Funder/Project Grant: |
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