Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Alternative architecture of the E. coli chemosensory array

Tools
- Tools
+ Tools

Burt, Alister, Cassidy, C. Keith, Stansfeld, Phillip J. and Gutsche, Irina (2021) Alternative architecture of the E. coli chemosensory array. Biomolecules, 11 (4). e495. doi:10.3390/biom11040495

[img]
Preview
PDF
WRAP-Alternative-architecture-E.-coli-chemosensory-array-2021.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (3657Kb) | Preview
Official URL: https://doi.org/10.3390/biom11040495

Request Changes to record.

Abstract

Chemotactic responses in motile bacteria are the result of sophisticated signal transduction by large, highly organized arrays of sensory proteins. Despite tremendous progress in the understanding of chemosensory array structure and function, a structural basis for the heightened sensitivity of networked chemoreceptors is not yet complete. Here, we present cryo-electron tomography visualisations of native-state chemosensory arrays in E. coli minicells. Strikingly, these arrays appear to exhibit a p2-symmetric array architecture that differs markedly from the p6-symmetric architecture previously described in E. coli. Based on this data, we propose molecular models of this alternative architecture and the canonical p6-symmetric assembly. We evaluate our observations and each model in the context of previously published data, assessing the functional implications of an alternative architecture and effects for future studies.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QR Microbiology
R Medicine > RC Internal medicine
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Science > Chemistry
Faculty of Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Escherichia coli, Chemical ecology, Chemotaxis, Cryoelectronics, Tomography, Molecules -- Models
Journal or Publication Title: Biomolecules
Publisher: MDPI
ISSN: 2218-273X
Official Date: 25 March 2021
Dates:
DateEvent
25 March 2021Published
23 March 2021Available
Volume: 11
Number: 4
Article Number: e495
DOI: 10.3390/biom11040495
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
647784Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661
BB/S003339/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
Related URLs:
  • https://creativecommons.org/licenses/by/...
  • Related dataset

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us