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Alternative architecture of the E. coli chemosensory array
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Burt, Alister, Cassidy, C. Keith, Stansfeld, Phillip J. and Gutsche, Irina (2021) Alternative architecture of the E. coli chemosensory array. Biomolecules, 11 (4). e495. doi:10.3390/biom11040495 ISSN 2218-273X.
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WRAP-Alternative-architecture-E.-coli-chemosensory-array-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (3657Kb) | Preview |
Official URL: https://doi.org/10.3390/biom11040495
Abstract
Chemotactic responses in motile bacteria are the result of sophisticated signal transduction by large, highly organized arrays of sensory proteins. Despite tremendous progress in the understanding of chemosensory array structure and function, a structural basis for the heightened sensitivity of networked chemoreceptors is not yet complete. Here, we present cryo-electron tomography visualisations of native-state chemosensory arrays in E. coli minicells. Strikingly, these arrays appear to exhibit a p2-symmetric array architecture that differs markedly from the p6-symmetric architecture previously described in E. coli. Based on this data, we propose molecular models of this alternative architecture and the canonical p6-symmetric assembly. We evaluate our observations and each model in the context of previously published data, assessing the functional implications of an alternative architecture and effects for future studies.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QR Microbiology R Medicine > RC Internal medicine T Technology > TK Electrical engineering. Electronics Nuclear engineering |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Chemistry > Computational and Theoretical Chemistry Centre |
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| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Escherichia coli, Chemical ecology, Chemotaxis, Cryoelectronics, Tomography, Molecules -- Models | |||||||||
| Journal or Publication Title: | Biomolecules | |||||||||
| Publisher: | MDPI | |||||||||
| ISSN: | 2218-273X | |||||||||
| Official Date: | 25 March 2021 | |||||||||
| Dates: |
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| Volume: | 11 | |||||||||
| Number: | 4 | |||||||||
| Article Number: | e495 | |||||||||
| DOI: | 10.3390/biom11040495 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 14 April 2021 | |||||||||
| Date of first compliant Open Access: | 14 April 2021 | |||||||||
| RIOXX Funder/Project Grant: |
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| Is Part Of: | 1 | |||||||||
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