Saravanan, Ponnusamy, Sukumar, Nithya, Adaikalakoteswari, Antonysunil, Goljan, Ilona, Venkataraman, Hema, Gopinath, Amitha, Bagias, Christos, Yajnik, Chittaranjan S., Stallard, Nigel, Ghebremichael-Weldeselassie, Yonas and Fall, Caroline (2021) Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes : a prospective UK cohort study (PRiDE study). Diabetologia, 64 . pp. 2170-2182. doi:10.1007/s00125-021-05510-7 ISSN 0012-186X.
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Abstract
OBJECTIVE To investigate the association of folate and vitamin B12 in early pregnancy with gestational diabetes mellitus (GDM) risk.
RESEARCH DESIGN AND METHODS The data of this study were from a subcohort within the Shanghai Preconception Cohort Study. We included pregnancies with red blood cell (RBC) folate and vitamin B12 measurements at recruitment (between 9 and 13 gestational weeks) and those with three samples available for glucose measurements under an oral glucose tolerance test. GDM was diagnosed between 24 and 28 weeks’ gestation. Odds ratio (OR) and 95% CI of having GDM was used to quantify the association.
RESULTS A total of 1,058 pregnant women were included, and GDM occurred in 180 (17.01%). RBC folate and vitamin B12 were significantly higher in pregnancies with GDM than those without GDM (P values were 0.045 and 0.002, respectively) and positively correlated with 1-h and 2-h serum glucose. Daily folic acid supplementation in early pregnancy increases the risk of GDM; OR (95% CI) was 1.73 (1.19–2.53) (P = 0.004). Compared with RBC folate <400 ng/mL, pregnancies with RBC folate ≥600 ng/mL were associated with ∼1.60-fold higher odds of GDM; the adjusted OR (95% CI) was 1.58 (1.03–2.41) (P = 0.033). A significant trend of risk effect on GDM risk across categories of RBC folate was observed (Ptrend = 0.021). Vitamin B12 was significantly associated with GDM risk (OR 1.14 per 100 pg/mL; P = 0.002). No significant association of serum folate and percentile ratio of RBC folate/vitamin B12 with GDM was observed.
CONCLUSIONS Higher maternal RBC folate and vitamin B12 levels in early pregnancy are significantly associated with GDM risk, while the balance of folate/vitamin B12 is not significantly associated with GDM.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Diabetes in pregnancy, Vitamin B12, Folic acid |
| Journal or Publication Title: | Diabetologia |
| Publisher: | Springer |
| ISSN: | 0012-186X |
| Official Date: | October 2021 |
| Dates: | Date Event October 2021 Published 22 July 2021 Available 28 April 2021 Accepted |
| Volume: | 64 |
| Page Range: | pp. 2170-2182 |
| DOI: | 10.1007/s00125-021-05510-7 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Copyright Holders: | © 2020 by the American Diabetes Association |
| Date of first compliant deposit: | 11 June 2021 |
| Date of first compliant Open Access: | 23 July 2021 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID |
| Related URLs: | |
| URI: | https://wrap.warwick.ac.uk/153962/ |
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