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A dynamic network of proteins facilitate cell envelope biogenesis in gram-negative bacteria
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Graham, Chris L. B., Newman, Hector, Gillett, Francesca, Smart, Katie, Briggs, Nicholas, Banzhaf, Manuel and Roper, David I. (2021) A dynamic network of proteins facilitate cell envelope biogenesis in gram-negative bacteria. International Journal of Molecular Sciences, 22 (23). e12831. doi:10.3390/ijms222312831 ISSN 1422-0067.
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Official URL: https://doi.org/10.3390/ijms222312831
Abstract
Bacteria must maintain the ability to modify and repair the peptidoglycan layer without jeopardising its essential functions in cell shape, cellular integrity and intermolecular interactions. A range of new experimental techniques is bringing an advanced understanding of how bacteria regulate and achieve peptidoglycan synthesis, particularly in respect of the central role played by complexes of Sporulation, Elongation or Division (SEDs) and class B penicillin-binding proteins required for cell division, growth and shape. In this review we highlight relationships implicated by a bioinformatic approach between the outer membrane, cytoskeletal components, periplasmic control proteins, and cell elongation/division proteins to provide further perspective on the interactions of these cell division, growth and shape complexes. We detail the network of protein interactions that assist in the formation of peptidoglycan and highlight the increasingly dynamic and connected set of protein machinery and macrostructures that assist in creating the cell envelope layers in Gram-negative bacteria.
| Item Type: | Journal Article | |||||||||||||||||||||
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| Subjects: | Q Science > QH Natural history | |||||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | |||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Peptidoglycans , Escherichia coli , Gram-negative bacteria, Cell division , Tight junctions (Cell biology) , Cytoskeleton | |||||||||||||||||||||
| Journal or Publication Title: | International Journal of Molecular Sciences | |||||||||||||||||||||
| Publisher: | MDPI | |||||||||||||||||||||
| ISSN: | 1422-0067 | |||||||||||||||||||||
| Official Date: | 27 November 2021 | |||||||||||||||||||||
| Dates: |
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| Volume: | 22 | |||||||||||||||||||||
| Number: | 23 | |||||||||||||||||||||
| Article Number: | e12831 | |||||||||||||||||||||
| DOI: | 10.3390/ijms222312831 | |||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | ** From MDPI via Jisc Publications Router ** History: accepted 03-11-2021; pub-electronic 27-11-2021. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
| Date of first compliant deposit: | 10 December 2021 | |||||||||||||||||||||
| Date of first compliant Open Access: | 13 December 2021 | |||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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