Larocque, Gabrielle and Royle, Stephen J. (2022) Integrating intracellular nanovesicles into integrin trafficking pathways and beyond. Cellular and Molecular Life Sciences, 79 (6). 335. doi:10.1007/s00018-022-04371-6 ISSN 1420-9071.
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Abstract
Membrane traffic controls the movement of proteins and lipids from one cellular compartment to another using a system of transport vesicles. Intracellular nanovesicles (INVs) are a newly described class of transport vesicles. These vesicles are small, carry diverse cargo, and are involved in multiple trafficking steps including anterograde traffic and endosomal recycling. An example of a biological process that they control is cell migration and invasion, due to their role in integrin recycling. In this review, we describe what is known so far about these vesicles. We discuss how INVs may integrate into established membrane trafficking pathways using integrin recycling as an example. We speculate where in the cell INVs have the potential to operate and we identify key questions for future investigation.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH426 Genetics |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| SWORD Depositor: | Library Publications Router |
| Library of Congress Subject Headings (LCSH): | Biological transport -- Regulation, Cell migration, Integrins, Cell adhesion molecules, Proteins -- Physiological transport |
| Journal or Publication Title: | Cellular and Molecular Life Sciences |
| Publisher: | Springer International Publishing |
| ISSN: | 1420-9071 |
| Official Date: | 3 June 2022 |
| Dates: | Date Event 3 June 2022 Published 11 May 2022 Accepted |
| Volume: | 79 |
| Number: | 6 |
| Article Number: | 335 |
| DOI: | 10.1007/s00018-022-04371-6 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 9 August 2022 |
| Date of first compliant Open Access: | 16 August 2022 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID |
| URI: | https://wrap.warwick.ac.uk/166730/ |
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