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The cortical regions and white matter tracts underlying auditory comprehension in patients with primary brain tumor
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Zhang, Jie, Yao, Ye, Wu, Jin‐song, Rolls, Edmund T., Sun, Ce‐chen, Bu, Ling‐hao, Lu, Jun‐feng, Lin, Ching‐po, Feng, Jianfeng, Mao, Ying and Zhou, Liang‐fu (2023) The cortical regions and white matter tracts underlying auditory comprehension in patients with primary brain tumor. Human Brain Mapping, 44 (4). pp. 1603-1616. doi:10.1002/hbm.26161 ISSN 1065-9471.
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Official URL: http://doi.org/10.1002/hbm.26161
Abstract
The comprehension of spoken language is one of the most essential language functions in humans. However, the neurological underpinnings of auditory comprehension remain under debate. Here we used multi-modal neuroimaging analyses on a group of patients with low-grade gliomas to localize cortical regions and white matter tracts responsible for auditory language comprehension. Region-of-interests and voxel-level whole-brain analyses showed that cortical areas in the posterior temporal lobe are crucial for language comprehension. The fiber integrity assessed with diffusion tensor imaging of the arcuate fasciculus and the inferior longitudinal fasciculus was strongly correlated with both auditory comprehension and the grey matter volume of the inferior temporal and middle temporal gyri. Together, our findings provide direct evidence for an integrated network of auditory comprehension whereby the superior temporal gyrus and sulcus, the posterior parts of the middle and inferior temporal gyri serve as auditory comprehension cortex, and the arcuate fasciculus and the inferior longitudinal fasciculus subserve as crucial structural connectivity. These findings provide critical evidence on the neural underpinnings of language comprehension.
Item Type: | Journal Article | ||||||||||||
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Subjects: | Q Science > QP Physiology | ||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||||||
Library of Congress Subject Headings (LCSH): | Brain -- Evolution, Auditory perception, Neuroimmunology , Cerebral cortex , White matter | ||||||||||||
Journal or Publication Title: | Human Brain Mapping | ||||||||||||
Publisher: | John Wiley and Sons | ||||||||||||
ISSN: | 1065-9471 | ||||||||||||
Official Date: | March 2023 | ||||||||||||
Dates: |
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Volume: | 44 | ||||||||||||
Number: | 4 | ||||||||||||
Page Range: | pp. 1603-1616 | ||||||||||||
DOI: | 10.1002/hbm.26161 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
Date of first compliant deposit: | 8 February 2023 | ||||||||||||
Date of first compliant Open Access: | 8 February 2023 | ||||||||||||
RIOXX Funder/Project Grant: |
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