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Autonomous microlasers for profiling extracellular vesicles from cancer spheroids
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Wang, Ziyihui, Fang, Guocheng, Gao, Zehang, Liao, Yikai, Gong, Chaoyang, Kim, Munho, Chang, Guo-En, Feng, Shilun, Xu, Tianhua, Liu, Tiegen and Chen, Yu-Cheng (2023) Autonomous microlasers for profiling extracellular vesicles from cancer spheroids. Nano Letters, 23 (7). pp. 2502-2510. doi:10.1021/acs.nanolett.2c04123 ISSN 1530-6984.
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WRAP-Autonomous-microlasers-visicles-cancer-spheroids-23.pdf - Accepted Version - Requires a PDF viewer. Download (1369Kb) | Preview |
Official URL: https://doi.org/10.1021/acs.nanolett.2c04123
Abstract
Self-propelled micro/nanomotors are emergent intelligent sensors for analyzing extracellular biomarkers in circulating biological fluids. Conventional luminescent motors are often masked by a highly dynamic and scattered environment, creating challenges to characterize biomarkers or subtle binding dynamics. Here we introduce a strategy to amplify subtle signals by coupling strong light–matter interactions on micromotors. A smart whispering-gallery-mode microlaser that can self-propel and analyze extracellular biomarkers is demonstrated through a liquid crystal microdroplet. Lasing spectral responses induced by cavity energy transfer were employed to reflect the abundance of protein biomarkers, generating exclusive molecular labels for cellular profiling of exosomes derived from 3D multicellular cancer spheroids. Finally, a microfluidic biosystem with different tumor-derived exosomes was employed to elaborate its sensing capability in complex environments. The proposed autonomous microlaser exhibits a promising method for both fundamental biological science and applications in drug screening, phenotyping, and organ-on-chip applications.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QH Natural history R Medicine > R Medicine (General) R Medicine > RC Internal medicine T Technology > TA Engineering (General). Civil engineering (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | |||||||||
Library of Congress Subject Headings (LCSH): | Semiconductor lasers, Biosensors , Cancer cells -- Diagnosis, Cancer -- Diseases -- Diagnosis, Liquid crystals , Photon detectors, Extracellular space, Tumor markers | |||||||||
Journal or Publication Title: | Nano Letters | |||||||||
Publisher: | American Chemical Society | |||||||||
ISSN: | 1530-6984 | |||||||||
Official Date: | 12 April 2023 | |||||||||
Dates: |
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Volume: | 23 | |||||||||
Number: | 7 | |||||||||
Page Range: | pp. 2502-2510 | |||||||||
DOI: | 10.1021/acs.nanolett.2c04123 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Re-use Statement: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.2c04123 | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Date of first compliant deposit: | 13 March 2023 | |||||||||
Date of first compliant Open Access: | 16 March 2024 | |||||||||
RIOXX Funder/Project Grant: |
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