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Acute iv CRH administration significantly increases serum active ghrelin in postmenopausal PCOS women compared to postmenopausal controls
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Markopoulos, M., Barber, Thomas M., Bargiota, A., Skevaki, C., Papassotiriou, I., Kumar, Sudhesh, Vlahos, N. F., Mastorakos, George and Valsamakis, Georgios (2023) Acute iv CRH administration significantly increases serum active ghrelin in postmenopausal PCOS women compared to postmenopausal controls. Endocrine, 81 . pp. 613-620. doi:10.1007/s12020-023-03406-7 ISSN 1355-008X.
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WRAP-acute-iv-CRH-administration-significantly-increases-serum-active-ghrelin-postmenopausal-PCOS-women-Barber-2023.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 30 May 2024. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Download (927Kb) |
Official URL: https://doi.org/10.1007/s12020-023-03406-7
Abstract
Purpose:
In women with Polycystic Ovarian Syndrome (PCOS), an increased risk of disordered eating has been described. There is growing interest regarding a possible interconnection between psychological states and increased appetite in women with PCOS. Acute stress is characterized by increased Corticotropin Releasing Hormone (CRH) secretion. The aim was to estimate the ghrelin concentrations during CRH test.
Methods:
Twenty postmenopausal women with PCOS and twenty age- and BMI- matched postmenopausal control women were recruited at Aretaieion University Hospital. In the morning (9 am) all subjects had anthropometric measurements (weight, height, waist circumference) and a fasting sample for hormonal measurements. An intravenous (iv) CRH stimulation test conducted over 1 min. Serum active ghrelin levels were measured at 0, 15, 30, 60, 90, 120 min after iv CRH administration.
Results:
The postmenopausal PCOS group had a higher waist circumference compared to postmenopausal controls. Active ghrelin concentrations increased significantly from 0 to 15 min, to 30 min, to 60 min, to 90 min and then decreased to 120 min. However, within the postmenopausal control group there were no significant changes in serum active ghrelin levels. Serum active ghrelin concentrations were significantly greater in the postmenopausal control group at 0, 15 and 120 min compared to the postmenopausal PCOS group. At 90 min active ghrelin concentrations were significantly greater in the postmenopausal PCOS group. Delta Area Under the Curve of active ghrelin (ΔAUCghr) was significantly greater in the postmenopausal PCOS group compared to controls.
Conclusions:
In postmenopausal PCOS, but not in postmenopausal controls, iv CRH administration induces increased serum active ghrelin secretion, suggesting a possible anti-stress adaptive mechanism. An increase in serum active ghrelin may induce hunger as a side-effect of this presumed adaptive mechanism.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Polycystic ovary syndrome , Polycystic Ovary Syndrome -- Etiology, Corticotropin releasing hormone, Menopause , Ghrelin | ||||||||
Journal or Publication Title: | Endocrine | ||||||||
Publisher: | Springer | ||||||||
ISSN: | 1355-008X | ||||||||
Official Date: | September 2023 | ||||||||
Dates: |
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Volume: | 81 | ||||||||
Page Range: | pp. 613-620 | ||||||||
DOI: | 10.1007/s12020-023-03406-7 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Re-use Statement: | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12020-023-03406-7 | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 7 June 2023 | ||||||||
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