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Altered gray-to-white matter tissue contrast in preterm-born adults
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Schmitz-Koep, Benita, Menegaux, Aurore, Zimmermann, Juliana, Thalhammer, Melissa, Neubauer, Antonia, Wendt, Jil, Schinz, David, Daamen, Marcel, Boecker, Henning, Zimmer, Claus, Priller, Josef, Wolke, Dieter, Bartmann, Peter, Sorg, Christian and Hedderich, Dennis M. (2023) Altered gray-to-white matter tissue contrast in preterm-born adults. CNS Neuroscience & Therapeutics, 29 (11). pp. 3199-3211. doi:10.1111/cns.14320 ISSN 1755-5930.
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Official URL: https://doi.org/10.1111/cns.14320
Abstract
Aims
To investigate cortical organization in brain magnetic resonance imaging (MRI) of preterm-born adults using percent contrast of gray-to-white matter signal intensities (GWPC), which is an in vivo proxy measure for cortical microstructure.
Methods
Using structural MRI, we analyzed GWPC at different percentile fractions across the cortex (0%, 10%, 20%, 30%, 40%, 50%, and 60%) in a large and prospectively collected cohort of 86 very preterm-born (<32 weeks of gestation and/or birth weight <1500 g, VP/VLBW) adults and 103 full-term controls at 26 years of age. Cognitive performance was assessed by full-scale intelligence quotient (IQ) using the Wechsler Adult Intelligence Scale.
Results
GWPC was significantly decreased in VP/VLBW adults in frontal, parietal, and temporal associative cortices, predominantly in the right hemisphere. Differences were pronounced at 20%, 30%, and 40%, hence, in middle cortical layers. GWPC was significantly increased in right paracentral lobule in VP/VLBW adults. GWPC in frontal and temporal cortices was positively correlated with birth weight, and negatively with duration of ventilation (p < 0.05). Furthermore, GWPC in right paracentral lobule was negatively correlated with IQ (p < 0.05).
Conclusions
Widespread aberrant gray-to-white matter contrast suggests lastingly altered cortical microstructure after preterm birth, mainly in middle cortical layers, with differential effects on associative and primary cortices.
Item Type: | Journal Article | |||||||||||||||||||||||||||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Brain -- Growth, Premature infants -- Development, Premature infants -- Growth, Cerebral cortex, Brain -- Imaging, Developmental neurobiology | |||||||||||||||||||||||||||||||||
Journal or Publication Title: | CNS Neuroscience & Therapeutics | |||||||||||||||||||||||||||||||||
Publisher: | Wiley | |||||||||||||||||||||||||||||||||
ISSN: | 1755-5930 | |||||||||||||||||||||||||||||||||
Official Date: | November 2023 | |||||||||||||||||||||||||||||||||
Dates: |
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Volume: | 29 | |||||||||||||||||||||||||||||||||
Number: | 11 | |||||||||||||||||||||||||||||||||
Page Range: | pp. 3199-3211 | |||||||||||||||||||||||||||||||||
DOI: | 10.1111/cns.14320 | |||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 11 July 2023 | |||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 12 July 2023 | |||||||||||||||||||||||||||||||||
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