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Monitoring the terahertz response of skin beneath transdermal drug delivery patches using sparse deconvolution
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Barker, Xavier E. Ramirez, Costa, Goncalo, Stantchev, Rayko I., Hernandez-Serrano, Arturo I., Nurumbetov, Gabit, Haddleton, David M. and Pickwell-MacPherson, Emma (2023) Monitoring the terahertz response of skin beneath transdermal drug delivery patches using sparse deconvolution. IEEE Transactions on Terahertz Science and Technology, 13 (5). pp. 503-510. doi:10.1109/TTHZ.2023.3292546 ISSN 2156-342X.
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WRAP-monitoring-terahertz-response-skin-beneath-transdermal-drug-delivery-patches-using-sparse-deconvolution-2023.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1192Kb) | Preview |
Official URL: http://dx.doi.org/10.1109/TTHZ.2023.3292546
Abstract
Terahertz (THz) spectroscopy is a technique proving extremely useful for investigating various biomedical applications by virtue of its high sensitivity in the measurement of water content and non-ionizing nature. By combining this with sparse deconvolution, the THz response of skin directly underneath transdermal drug delivery (TDD) patches was isolated and reconstructed to determine the skin water content in vivo. Verification for this method was given by a comparison of skin measured through patches using sparse deconvolution, and skin measurements immediately following patch removal processed with standard approaches. It was found that patches with a non-permeable film backing hydrated the skin to a greater extent than permeable woven polyester fiber backed patches and that this hydration effect primarily occurs within the first 30 minutes of patch application and lasts for at least 24 hours given that the patch remains applied. We demonstrate the effectiveness of this sparse reconstruction method to track hydration levels through layers such as patches and identify scope for further applications including TDD patch development and wound healing techniques and monitoring.
Item Type: | Journal Article | ||||||||||||
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Subjects: | Q Science > QC Physics Q Science > QP Physiology R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology T Technology > TA Engineering (General). Civil engineering (General) T Technology > TK Electrical engineering. Electronics Nuclear engineering |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics |
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Library of Congress Subject Headings (LCSH): | Biomedical engineering, Terahertz technology, Transdermal medication, Terahertz spectroscopy , Skin -- Physiology, Photonics, Skin absorption | ||||||||||||
Journal or Publication Title: | IEEE Transactions on Terahertz Science and Technology | ||||||||||||
Publisher: | IEEE | ||||||||||||
ISSN: | 2156-342X | ||||||||||||
Official Date: | September 2023 | ||||||||||||
Dates: |
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Volume: | 13 | ||||||||||||
Number: | 5 | ||||||||||||
Page Range: | pp. 503-510 | ||||||||||||
DOI: | 10.1109/TTHZ.2023.3292546 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
Date of first compliant deposit: | 2 August 2023 | ||||||||||||
Date of first compliant Open Access: | 4 August 2023 | ||||||||||||
RIOXX Funder/Project Grant: |
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