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A quantitative morphospace of multicellular organ design in the plant Arabidopsis
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Duran-Nebreda, Salva, Jackson, Matthew D. B. and Bassel, George W. (2023) A quantitative morphospace of multicellular organ design in the plant Arabidopsis. Current biology, 33 (22). 4798-4806.e3. doi:10.1016/j.cub.2023.09.048 ISSN 1879-0445.
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Official URL: https://doi.org/10.1016/j.cub.2023.09.048
Abstract
Organ function emerges from the interactions between their constituent cells. The investigation of cellular organization can provide insight into organ function following structure-function relationships. Here, we investigate the extent to which properties in cellular organization can arise "for free" as an emergent property of embedding cells in space versus those that are actively generated by patterning processes. Default cellular configurations were established using three-dimensional (3D) digital tissue models. Network-based analysis of these synthetic cellular assemblies established a quantitative topological baseline of cellular organization, granted by virtue of passive spatial packing and the minimal amount of order that emerges for free in tessellated tissues. A 3D cellular-resolution digital tissue atlas for the model plant species Arabidopsis was generated, and the extent to which the organs in this organism conform to the default configurations was established through statistical comparisons with digital tissue models. Cells in different tissues of Arabidopsis do not conform to random packing arrangements to varying degrees. Most closely matching the random models was the undifferentiated shoot apical meristem (SAM) from which aerial organs emanate. By contrast, leaf and sepal tissue showed the greatest deviation from this baseline, suggesting these to be the most "complex" tissues in Arabidopsis. Investigation of the patterning principles responsible for the gap between these tissues and default patterns revealed cell elongation and the introduction of air spaces to contribute toward additional organ patterning complexity. This work establishes a quantitative morphospace to understand the principles of organ construction and its diversity within a single organism.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QH Natural history Q Science > QK Botany |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Arabidopsis, Cellular control mechanisms , Multicellularity | |||||||||||||||||||||
Journal or Publication Title: | Current biology | |||||||||||||||||||||
Publisher: | Elsevier | |||||||||||||||||||||
ISSN: | 1879-0445 | |||||||||||||||||||||
Official Date: | 3 October 2023 | |||||||||||||||||||||
Dates: |
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Volume: | 33 | |||||||||||||||||||||
Number: | 22 | |||||||||||||||||||||
Page Range: | 4798-4806.e3 | |||||||||||||||||||||
DOI: | 10.1016/j.cub.2023.09.048 | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 1 December 2023 | |||||||||||||||||||||
Date of first compliant Open Access: | 1 December 2023 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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