Akman, Ozgur E., Locke, James C. W., Tang, Sanyi, Carré, Isabelle A., Millar, A. J. (Andrew J.) and Rand, D. A. (David A.) (2008) Isoform switching facilitates period control in the Neurospora crassa circadian clock. Molecular Systems Biology, Volume 4 . Article No. 164. doi:10.1038/msb.2008.5 ISSN 1744-4292.
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Abstract
A striking and defining feature of circadian clocks is the small variation in period over a physiological range of temperatures. This is referred to as temperature compensation, although recent work has suggested that the variation observed is a specific, adaptive control of period. Moreover, given that many biological rate constants have a Q(10) of around 2, it is remarkable that such clocks remain rhythmic under significant temperature changes. We introduce a new mathematical model for the Neurospora crassa circadian network incorporating experimental work showing that temperature alters the balance of translation between a short and long form of the FREQUENCY ( FRQ) protein. This is used to discuss period control and functionality for the Neurospora system. The model reproduces a broad range of key experimental data on temperature dependence and rhythmicity, both in wild-type and mutant strains. We present a simple mechanism utilising the presence of the FRQ isoforms (isoform switching) by which period control could have evolved, and argue that this regulatory structure may also increase the temperature range where the clock is robustly rhythmic.
Item Type: | Journal Article |
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
Library of Congress Subject Headings (LCSH): | Circadian rhythms, Body temperature -- Regulation, Biological control systems -- Mathematical models, Neurospora crassa |
Journal or Publication Title: | Molecular Systems Biology |
Publisher: | Nature Publishing Group |
ISSN: | 1744-4292 |
Official Date: | February 2008 |
Dates: | Date Event February 2008 Published |
Volume: | Volume 4 |
Number of Pages: | 11 |
Page Range: | Article No. 164 |
DOI: | 10.1038/msb.2008.5 |
Status: | Peer Reviewed |
Publication Status: | Published |
Access rights to Published version: | Restricted or Subscription Access |
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), European Union (EU) |
Grant number: | 005137 (EU) |
URI: | https://wrap.warwick.ac.uk/30464/ |
Data sourced from Thomson Reuters' Web of Knowledge
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