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Synthesis and cytotoxicity of dinuclear complexes containing ruthenium(II) bipyridyl units linked by a bis(pyridylimine) ligand
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McDonnell, Ursula, Kerchoffs, Jessica M. C. A., Castineiras, Rosa P. M., Hicks, Matthew R., Hotze, Anna C. G., Hannon, M. J. (Michael J.) and Rodger, Alison (2008) Synthesis and cytotoxicity of dinuclear complexes containing ruthenium(II) bipyridyl units linked by a bis(pyridylimine) ligand. Dalton Transactions, Vol.37 (No.5). pp. 667-675. doi:10.1039/b711080d ISSN 1477-9226.
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Official URL: http://dx.doi.org/10.1039/b711080d
Abstract
Enantiopure dinuclear ruthenium polypyridyl complexes of the form [Ru-2(LL)(4)L-1](PF6)(4) (LL = 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen); L-1 = C25H20N4 a bis(pyridylimine) ligand containing a diphenylmethane spacer) have been synthesized using the chiral building blocks cis-[Ru(bpy)(2)(py)(2)](2+) and cis-[Ru(phen)(2)(py)(2)](2+). These dinuclear ruthenium complexes have been characterised using NMR, mass spectrometry, UV-visible absorbance, circular dichroism and linear dichroism. The compounds exhibit good photo and thermal stability. The extinction coefficient for the bpy complex at 478 nm is epsilon(478) = 15 700 mol(-1) cm(-1) dm(3) and for the phen complex is epsilon(478) = 24900 mol(-1) cm(-1) dm(3). Both complexes have their longest wavelength (metal to ligand charge transfer) transition predominantly x/y (short axis)-polarised while the transitions at shorter wavelength are a mixture of x/y and z-polarisations, similar to both the copper helicate and iron triple helicate studied previously. Cytotoxicity studies reveal that the compounds are dramatically less active against cancer cell lines than the recently reported supramolecular cylinders prepared from the same bis(pyridylimine) ligand.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Transition metal complexes, Antineoplastic agents, Enantiomers, Electrochemistry, Ruthenium | ||||
| Journal or Publication Title: | Dalton Transactions | ||||
| Publisher: | Royal Society of Chemistry | ||||
| ISSN: | 1477-9226 | ||||
| Official Date: | 7 February 2008 | ||||
| Dates: |
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| Volume: | Vol.37 | ||||
| Number: | No.5 | ||||
| Number of Pages: | 9 | ||||
| Page Range: | pp. 667-675 | ||||
| DOI: | 10.1039/b711080d | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), European Union (EU), Fundación Ramón Areces | ||||
| Grant number: | MEIF-CT-2005-024818 (EU), HPRNCT- 2002-00175 (EU) |
Data sourced from Thomson Reuters' Web of Knowledge
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