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Apoptosis of neurons in the vestibular nuclei of adult mice results from prolonged change in the external environment
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Mitchell, Ian John, Cooper, A. J., Brown, G. D. A. (Gordon D. A.) and Waters, C. M.. (1995) Apoptosis of neurons in the vestibular nuclei of adult mice results from prolonged change in the external environment. Neuroscience Letters, Vol.198 (No.3). pp. 153-156. ISSN 0304-3940
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Official URL: http://dx.doi.org/10.1016/0304-3940(95)11969-4
Abstract
Pharmacological manipulations which result in abnormal levels of excitatory amino acid (EAA) mediated neurotransmission can result in neuronal apoptosis. We accordingly hypothesised that manipulations of the external environment which induce prolonged EAA-mediated transmission in sensory neurons may also induce apoptosis. This hypothesis was tested by placing groups of adult mice, housed in their home cage, on a turntable which slowly rotated (0.8 rev./min). This non-invasive manipulation will have resulted in abnormal discharge patterns in the vestibular nuclei. Significantly greater levels of neuronal apoptosis were seen in the vestibular complex after rotation for 48 h compared with non-rotated controls. This finding was also predicted independently from a computational approach.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Faculty of Science > Psychology |
| Library of Congress Subject Headings (LCSH): | Apoptosis, Neurons, Vestibular nuclei, Mice -- Physiology, Animal cages -- Experiments, Sensory stimulation, Excitatory amino acids |
| Journal or Publication Title: | Neuroscience Letters |
| Publisher: | Elsevier Ireland Ltd |
| ISSN: | 0304-3940 |
| Official Date: | 1995 |
| Volume: | Vol.198 |
| Number: | No.3 |
| Page Range: | pp. 153-156 |
| Identification Number: | 10.1016/0304-3940(95)11969-4 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Medical Research Council (Great Britain) (MRC), Wellcome Trust (London, England) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/37210 |
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