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Apoptosis of neurons in the vestibular nuclei of adult mice results from prolonged change in the external environment

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Mitchell, Ian John, Cooper, A. J., Brown, G. D. A. (Gordon D. A.) and Waters, C. M. (1995) Apoptosis of neurons in the vestibular nuclei of adult mice results from prolonged change in the external environment. Neuroscience Letters, Vol.198 (No.3). pp. 153-156. doi:10.1016/0304-3940(95)11969-4 ISSN 0304-3940.

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Official URL: http://dx.doi.org/10.1016/0304-3940(95)11969-4

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Abstract

Pharmacological manipulations which result in abnormal levels of excitatory amino acid (EAA) mediated neurotransmission can result in neuronal apoptosis. We accordingly hypothesised that manipulations of the external environment which induce prolonged EAA-mediated transmission in sensory neurons may also induce apoptosis. This hypothesis was tested by placing groups of adult mice, housed in their home cage, on a turntable which slowly rotated (0.8 rev./min). This non-invasive manipulation will have resulted in abnormal discharge patterns in the vestibular nuclei. Significantly greater levels of neuronal apoptosis were seen in the vestibular complex after rotation for 48 h compared with non-rotated controls. This finding was also predicted independently from a computational approach.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Science, Engineering and Medicine > Science > Psychology
Library of Congress Subject Headings (LCSH): Apoptosis, Neurons, Vestibular nuclei, Mice -- Physiology, Animal cages -- Experiments, Sensory stimulation, Excitatory amino acids
Journal or Publication Title: Neuroscience Letters
Publisher: Elsevier Ireland Ltd
ISSN: 0304-3940
Official Date: 1995
Dates:
DateEvent
1995Published
Volume: Vol.198
Number: No.3
Page Range: pp. 153-156
DOI: 10.1016/0304-3940(95)11969-4
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Medical Research Council (Great Britain) (MRC), Wellcome Trust (London, England)

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