Selenium status and blood lipids : the cardiovascular risk in young Finns study

Research output not available from this repository.

Request-a-Copy directly from author or use local Library Get it For Me service.

Request Changes to record.

Abstract

Background. Concern has been recently raised about possible adverse cardio-metabolic effects of high selenium status, such as increased risks of diabetes and hyperlipidaemia. However, most of the evidence comes from selenium-replete populations such as that of the United States.

Objectives. To examine cross-sectional and longitudinal associations of serum selenium with cardiovascular risk factors in Finland where selenium levels were amongst the lowest in the world until the early 1980s before the implementation of a nationwide selenium fertilization programme.

Methods. Serum selenium was measured in 1235 young Finns aged 3-18 years at baseline in 1980 (prefertilization) and in a subgroup (N = 262) at the 6-year follow-up (1986, postfertilization). During the 27-year follow-up, serumlipids, blood pressure, body mass index and smoking were assessed five times (1980,1983,1986,2001 and 2007).

Results. Mean (+/-SD) serum selenium concentrations were 74.3 +/- 14.0 ng mL(-1) in 1980 and 106.6 +/- 12.5 ng mL(-1) in 1986 (average increase 32.3 ng mL(-1); 95% CI: 30.3 to 34.3, P < 0.0001). In univariate and multivariable cross-sectional models in 1980 and 1986, increased serum selenium levels were consistently associated with increased total, HDL and Low-density lipoprotein (LDL) cholesterol. However, the average longitudinal changes in lipids were -0.20 mmol L(-1) (95% CI: -0.30 to -0.10, P < 0.0001) for total cholesterol, 0.06 mmol L(-1) (95% CI: 0.03 to 0.10, P < 0.0001) for HDL cholesterol, and) 0.23 mmol L(-1) (95% CI: -0.31 to -0.14, P < 0.0001) for LDL cholesterol. Selenium measured in 1986 was not associated with lipids assessed in 2001 and 2007.

Conclusions. Cross-sectional findings from the Young Finns study corroborate positive associations of selenium status with serum lipids. However, longitudinal evidence does not support the causality of this link.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Selenium, Blood lipids, Young adults -- Health and hygiene -- Finland, Cardiovascular system -- Diseases -- Risk factors -- Finland, Cardiovascular system -- Diseases -- Longitudinal studies
Journal or Publication Title: Journal of Internal Medicine
Publisher: Wiley-Blackwell Publishing Ltd.
ISSN: 0954-6820
Official Date: November 2011
Dates:
Date
Event
November 2011
Published
Volume: Volume 270
Number: Number 5
Page Range: pp. 469-477
DOI: 10.1111/j.1365-2796.2011.02398.x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Suomen Akatemia [Academy of Finland] (SF), Kansaneläkelaitos (Finland) [Social Insurance Institution, Finland], Turun Yliopistosaatio [Turku University Foundation] (TY), Kuopio University Hospital, Emil Aaltonen Foundation, Juho Vainio Foundation, Finnish Foundation of Cardiovascular Research, Suomen Kulttuurirahasto [Finnish Cultural Foundation] (SK), National Heart, Lung, and Blood Institute (NHLBI), National Institute on Aging (NIA), British United Provident Association (BUPA), Turku University Hospital, Tampere University Hospital
Grant number: 77841 (SF), 117832 (SF), 201888 (SF), 121584 (SF), R01 HL036310-20A2 (NHLBI), R01AG034454 (NIA),
URI: https://wrap.warwick.ac.uk/40434/

Export / Share Citation


Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item