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An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(II) metallo-drug
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Huxley, Martin, Sanchez-Cano, Carlos, Browning, Michael J., Navarro-Ranninger, Carmen, Quiroga, Adoracion G., Rodger, Alison and Hannon, M. J. (Michael J.) (2010) An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(II) metallo-drug. Dalton Transactions, Vol.39 (No.47). pp. 11353-11364. doi:10.1039/c0dt00838a ISSN 1477-9226.
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Official URL: http://dx.doi.org/10.1039/c0dt00838a
Abstract
A range of androgen conjugates with non-conventional platinum(II) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(II) complex resulted in synergistic effects between the metallic centre and the steroidal ligand, creating highly potent platinum(II) complexes from the inactive components.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Platinum -- Therapeutic use, Estrogen -- Receptors, Progesterone -- Receptors, Cells -- Effect of drugs on, Radioligand assay, Breast -- Cancer, Ovaries -- Cancer, Androgens | ||||
| Journal or Publication Title: | Dalton Transactions | ||||
| Publisher: | Royal Society of Chemistry | ||||
| ISSN: | 1477-9226 | ||||
| Official Date: | 21 December 2010 | ||||
| Dates: |
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| Volume: | Vol.39 | ||||
| Number: | No.47 | ||||
| Number of Pages: | 12 | ||||
| Page Range: | pp. 11353-11364 | ||||
| DOI: | 10.1039/c0dt00838a | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), University of Birmingham, University of Warwick, Spain. Comisión Interministerial de Ciencia y TecnologÃa (CICYT) | ||||
| Grant number: | SAF 2006-03296 (CICYT), SAF 2009-0431 (CICYT) |
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