Antzutkin, Oleg N., Iuga, Dinu, Filippov, Andrei V., Kelly, Robert T., Becker-Baldus, Johanna, Brown, Steven P. and Dupree, Ray (2012) Hydrogen Bonding in Alzheimer’s Amyloid-β Fibrils Probed by15N{17O} REAPDOR Solid-State NMR Spectroscopy. Angewandte Chemie International Edition, Vol. 51 (No. 41). pp. 10289-10292. doi:10.1002/anie.201203595 ISSN 1433-7851.
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Abstract
An exclusive label: 15N{17O} REAPDOR NMR was used to validate intermolecular C17O⋅⋅⋅H15N hydrogen bonding in Ac-Aβ(16–22)-NH2 (see scheme) and Aβ(11–25) amyloid fibrils, which are associated with Alzheimer's disease, by selectively labeling them with 17O and 15N. This method was effective for confirming the structure of these fibrils, and could be useful for a number of other biological samples.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QP Physiology |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics |
| Library of Congress Subject Headings (LCSH): | Hydrogen bonding, Amyloid, Alzheimer's disease -- Physiological aspects |
| Journal or Publication Title: | Angewandte Chemie International Edition |
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
| ISSN: | 1433-7851 |
| Official Date: | 2012 |
| Dates: | Date Event 2012 Published |
| Volume: | Vol. 51 |
| Number: | No. 41 |
| Page Range: | pp. 10289-10292 |
| DOI: | 10.1002/anie.201203595 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID UNSPECIFIED [EPSRC] Engineering and Physical Sciences Research Council |
| Related URLs: | |
| URI: | https://wrap.warwick.ac.uk/52025/ |
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