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Hydrogen Bonding in Alzheimer’s Amyloid-β Fibrils Probed by15N{17O} REAPDOR Solid-State NMR Spectroscopy
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Antzutkin, Oleg N., Iuga, Dinu, Filippov, Andrei V., Kelly, Robert T., Becker-Baldus, Johanna, Brown, Steven P. and Dupree, Ray. (2012) Hydrogen Bonding in Alzheimer’s Amyloid-β Fibrils Probed by15N{17O} REAPDOR Solid-State NMR Spectroscopy. Angewandte Chemie International Edition, Vol. 51 (No. 41). pp. 10289-10292. ISSN 1433-7851
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Official URL: http://dx.doi.org/10.1002/anie.201203595
Abstract
An exclusive label: 15N{17O} REAPDOR NMR was used to validate intermolecular C17O⋅⋅⋅H15N hydrogen bonding in Ac-Aβ(16–22)-NH2 (see scheme) and Aβ(11–25) amyloid fibrils, which are associated with Alzheimer's disease, by selectively labeling them with 17O and 15N. This method was effective for confirming the structure of these fibrils, and could be useful for a number of other biological samples.
| Item Type: | Journal Article |
|---|---|
| Divisions: | Faculty of Science > Physics |
| Journal or Publication Title: | Angewandte Chemie International Edition |
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
| ISSN: | 1433-7851 |
| Date: | 2012 |
| Volume: | Vol. 51 |
| Number: | No. 41 |
| Page Range: | pp. 10289-10292 |
| Identification Number: | 10.1002/anie.201203595 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/52025 |
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