Sperati, Francesca, Vici, Patrizia, Maugeri-Saccà, Marcello, Stranges, Saverio, Santesso, Nancy, Mariani, Luciano, Giordano, Antonio, MD, Sergi, Domenico, Pizzuti, Laura, Di Lauro, Luigi, Montella, Maurizio, Crispo, Anna, Mottolese, Marcella and Barba, Maddalena (2013) Vitamin D supplementation and breast cancer prevention : a systematic review and meta-analysis of randomized clinical trials. PLoS One, Volume 8 (Number 7). Article number e69269. doi:10.1371/journal.pone.0069269 ISSN 1932-6203.
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Abstract
In recent years, the scientific evidence linking vitamin D status or supplementation to breast cancer has grown notably. To investigate the role of vitamin D supplementation on breast cancer incidence, we conducted a systematic review and meta-analysis of randomized controlled trials comparing vitamin D with placebo or no treatment. We used OVID to search MEDLINE (R), EMBASE and CENTRAL until April 2012. We screened the reference lists of included studies and used the “Related Article” feature in PubMed to identify additional articles. No language restrictions were applied. Two reviewers independently extracted data on methodological quality, participants, intervention, comparison and outcomes. Risk Ratios and 95% Confident Intervals for breast cancer were pooled using a random-effects model. Heterogeneity was assessed using the I2 test. In sensitivity analysis, we assessed the impact of vitamin D dosage and mode of administration on treatment effects. Only two randomized controlled trials fulfilled the pre-set inclusion criteria. The pooled analysis included 5372 postmenopausal women. Overall, Risk Ratios and 95% Confident Intervals were 1.11 and 0.74–1.68. We found no evidence of heterogeneity. Neither vitamin D dosage nor mode of administration significantly affected breast cancer risk. However, treatment efficacy was somewhat greater when vitamin D was administered at the highest dosage and in combination with calcium (Risk Ratio 0.58, 95% Confident Interval 0.23–1.47 and Risk Ratio 0.93, 95% Confident Interval 0.54–1.60, respectively). In conclusions, vitamin D use seems not to be associated with a reduced risk of breast cancer development in postmenopausal women. However, the available evidence is still limited and inadequate to draw firm conclusions. Study protocol code: FARM8L2B5L.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Vitamin D, Breast -- Cancer, Breast -- Cancer -- Research, Vitamin therapy, Vitamin D -- Therapeutic use, Systematic reviews (Medical research) , Clinical trials |
| Journal or Publication Title: | PLoS One |
| Publisher: | Public Library of Science |
| ISSN: | 1932-6203 |
| Official Date: | 2013 |
| Dates: | Date Event 2013 Published |
| Volume: | Volume 8 |
| Number: | Number 7 |
| Page Range: | Article number e69269 |
| DOI: | 10.1371/journal.pone.0069269 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 25 December 2015 |
| Date of first compliant Open Access: | 25 December 2015 |
| Funder: | Agenzia italiana del farmaco (AIFA) |
| Grant number: | FARM8L2B5L (AIFA) |
| URI: | https://wrap.warwick.ac.uk/55713/ |
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