Beevers, Andrew J. and Dixon, Ann M. (2010) Helical membrane peptides to modulate cell function. Chemical Society Reviews, Vol.39 (No.6). pp. 2146-2157. ISSN 0306-0012

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Abstract

In recent years there has been an abundance of research into the potential of helical peptides to influence cell function. These peptides have been used to achieve a variety of different outcomes from cell repair to cell death, depending upon the peptide sequence and the nature of its interactions with cell membranes and membrane proteins. In this critical review, we summarise several mechanisms by which helical peptides, acting as either transporters, inhibitors, agonists or antibiotics, can have significant effects on cell membranes and can radically affect the internal mechanisms of the cell. The various approaches to peptide design are discussed, including the role of naturally-occurring proteins in the design of these helical peptides and current breakthroughs in the use of non-natural (and therefore more stable) peptide scaffolds. Most importantly, the current successful applications of these peptides, and their potential uses in the field of medicine, are reviewed.

Item Type:	Journal Item
Subjects:	Q Science > QD Chemistry Q Science > QP Physiology
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Peptides, Cell physiology, Cellular signal transduction, Cell membranes
Journal or Publication Title:	Chemical Society Reviews
Publisher:	Royal Society of Chemistry
ISSN:	0306-0012
Date:	June 2010
Volume:	Vol.39
Number:	No.6
Number of Pages:	12
Page Range:	pp. 2146-2157
Identification Number:	10.1039/b912944h
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/5837

Data sourced from Thomson Reuters' Web of Knowledge

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