Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, James W. T. and Evans, Neil D. (2014) Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake. Computer Methods and Programs in Biomedicine, Volume 114 (Number 3). e60-e69. doi:10.1016/j.cmpb.2013.06.013 ISSN 0169-2607.
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Abstract
In this paper a review of the application of four different techniques (a version of the similarity transformation approach for autonomous uncontrolled systems, a non-differential input/output observable normal form approach, the characteristic set differential algebra and a recent algebraic input/output relationship approach) to determine the structural identifiability of certain in vitro nonlinear pharmacokinetic models is provided. The Organic Anion Transporting Polypeptide (OATP) substrate, Pitavastatin, is used as a probe on freshly isolated animal and human hepatocytes. Candidate pharmacokinetic non-linear compartmental models have been derived to characterise the uptake process of Pitavastatin. As a prerequisite to parameter estimation, structural identifiability analyses are performed to establish that all unknown parameters can be identified from the experimental observations available.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology T Technology > TA Engineering (General). Civil engineering (General) |
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering |
| Library of Congress Subject Headings (LCSH): | Liver cells, Cell metabolism, Drugs -- Metabolism -- Evaluation, Algebra |
| Journal or Publication Title: | Computer Methods and Programs in Biomedicine |
| Publisher: | Elsevier Ireland Ltd. |
| ISSN: | 0169-2607 |
| Official Date: | May 2014 |
| Dates: | Date Event May 2014 Published |
| Volume: | Volume 114 |
| Number: | Number 3 |
| Page Range: | e60-e69 |
| DOI: | 10.1016/j.cmpb.2013.06.013 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 26 December 2015 |
| Date of first compliant Open Access: | 26 December 2015 |
| Funder: | Medical Research Council (Great Britain) (MRC), AstraZeneca (Firm) |
| URI: | https://wrap.warwick.ac.uk/59157/ |
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