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Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level : lessons from Dictyostelium
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Bretschneider, Till, Othmer, Hans G. and Weijer, Cornelis J. (2016) Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level : lessons from Dictyostelium. Interface Focus, 6 (5). 20160047. ISSN 2042-8898.
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Official URL: http://dx.doi.org/10.1098/rsfs.2016.0047
Abstract
Movement of cells and tissues is a basic biological process that is used in development, wound repair, the immune response to bacterial invasion, tumour formation and metastasis, and the search for food and mates. While some cell movement is random, directed movement stimulated by extracellular signals is our focus here. This involves a sequence of steps in which cells first detect extracellular chemical and/or mechanical signals via membrane receptors that activate signal transduction cascades and produce intracellular signals. These intracellular signals control the motile machinery of the cell and thereby determine the spatial localization of the sites of force generation needed to produce directed motion. Understanding how force generation within cells and mechanical interactions with their surroundings, including other cells, are controlled in space and time to produce cell-level movement is a major challenge, and involves many issues that are amenable to mathematical modelling.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QP Physiology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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Library of Congress Subject Headings (LCSH): | Cellular signal transduction, Cell membranes | ||||||||
Journal or Publication Title: | Interface Focus | ||||||||
Publisher: | The Royal Society Publishing | ||||||||
ISSN: | 2042-8898 | ||||||||
Official Date: | 6 October 2016 | ||||||||
Dates: |
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Volume: | 6 | ||||||||
Number: | 5 | ||||||||
Article Number: | 20160047 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Date of first compliant deposit: | 12 October 2016 | ||||||||
Date of first compliant Open Access: | 19 August 2017 | ||||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), National Science Foundation (U.S.) (NSF), Simons Foundation (SF), Isaac Newton Institute for Mathematical Sciences | ||||||||
Grant number: | BB/M01150X/1, BB/L00271X/1 (BBSRC), DMS#s 9517884 and 131974 (NSF) |
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