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Gender- and gamete-specific patterns of X chromosome segregation in a three-gendered nematode
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Tandonnet, Sophie, Farrell, Maureen C., Koutsovoulos, Georgios, Blaxter, Mark, Parihar, Manish, Sadler, Penny L., Shakes, Diane and Pires-da Silva, André Francisco (2017) Gender- and gamete-specific patterns of X chromosome segregation in a three-gendered nematode. Working Paper. BioRxiv: Cold Spring Harbour Laboratory. (Unpublished)
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Official URL: http://dx.doi.org/10.1101/205211
Abstract
Meiosis is at the core of sexual reproduction and alterations to its program can have dramatic effects. In this study, we investigate the segregation pattern of the X chromosome in Auanema rhodensis, a three-gendered nematode. This species has an atypical pattern of X chromosome segregation during male spermatogenesis that results in the exclusive production of haplo-X sperm. Here we use a combination of genetic and cytological approaches to show that while XX females undergo conventional meiosis to produce mostly haplo-X oocytes, hermaphrodites undergo atypical meiosis to produce nullo-X oocytes and mostly diplo-X sperm. Gender- and gamete-specific alterations of the normal meiotic program include non-pairing of the X homologs and precocious separation of X chromatids. Given these intra-species, intra-individual and intra-gametogenesis variations in meiotic program of A. rhodensis, we argue that it is an ideal model to study the plasticity of meiosis and how it can be modulated.
Item Type: | Working or Discussion Paper (Working Paper) | ||||
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Subjects: | Q Science > QH Natural history | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Meiosis, Nematodes -- Genetics, X chromosome -- Abnormalities, Aneuploidy | ||||
Publisher: | Cold Spring Harbour Laboratory | ||||
Place of Publication: | BioRxiv | ||||
Book Title: | Gender- and gamete-specific patterns of X chromosome segregation in a three-gendered nematode | ||||
Official Date: | 18 October 2017 | ||||
Dates: |
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Number: | 205211 | ||||
DOI: | 10.1101/205211 | ||||
Institution: | University of Warwick | ||||
Status: | Not Peer Reviewed | ||||
Publication Status: | Unpublished | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Brazil. Coordenação do Aperfeiçoamento de Pessoal de Nível Superior (CAPES), National Science Foundation (U.S.) (NSF), University of Warwick | ||||
Grant number: | 201116/2014-6; IOS 1122095; BB/L019884/1; IOS 1122101 |
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