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Engineering microbial communities using thermodynamic principles and electrical interfaces
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Zerfaß, Christian, Chen, Jing and Soyer, Orkun S. (2018) Engineering microbial communities using thermodynamic principles and electrical interfaces. Current Opinion in Biotechnology, 50 . pp. 121-127.
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WRAP-engineering-microbial-communities-thermodynamic-principles-Soyer-2017.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (511Kb) |
Official URL: https://doi.org/10.1016/j.copbio.2017.12.004
Abstract
Microbial communities present the next research frontier. We argue here that understanding and engineering microbial communities requires a holistic view that considers not only species-species, but also species-environment interactions and feedbacks between ecological and evolutionary dynamics (eco-evo feedbacks). Due this multi-level nature of interactions, we predict that approaches aimed soley at altering specific species populations in a community (through strain enrichment or inhibition), would only have a transient impact, and species-environment and eco-evo feedbacks would eventually drive the microbial community to its original state. We propose a higher-level engineering approach that is based on thermodynamics of microbial growth, and that considers specifically microbial redox biochemistry. Within this approach the emphasis is on enforcing specific environmental conditions onto the community, that generates higher-level thermodynamic bounds onto the system, which the community structure and function can then adapt to. We believe that the resulting end-state can be ecologically and evolutionarily stable, mimicking the natural states of complex communities. Towards designing the exact nature of the environmental enforcement, thermodynamics and redox biochemistry can act as coarse-grained principles, while the use of electrodes - as electron providing or accepting redox agents - can provide implementation with spatiotemporal control.
| Item Type: | Journal Article | |||||||||
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| Subjects: | T Technology > TP Chemical technology | |||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | Biochemical engineering, Biotechnology | |||||||||
| Journal or Publication Title: | Current Opinion in Biotechnology | |||||||||
| Publisher: | Elsevier Ltd. | |||||||||
| ISSN: | 0958-1669 | |||||||||
| Official Date: | April 2018 | |||||||||
| Dates: |
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| Date of first compliant deposit: | 8 December 2017 | |||||||||
| Volume: | 50 | |||||||||
| Page Range: | pp. 121-127 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| RIOXX Funder/Project Grant: |
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