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Engineering microbial communities using thermodynamic principles and electrical interfaces

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Zerfaß, Christian, Chen, Jing and Soyer, Orkun S. (2018) Engineering microbial communities using thermodynamic principles and electrical interfaces. Current Opinion in Biotechnology, 50 . pp. 121-127.

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Official URL: https://doi.org/10.1016/j.copbio.2017.12.004

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Abstract

Microbial communities present the next research frontier. We argue here that understanding and engineering microbial communities requires a holistic view that considers not only species-species, but also species-environment interactions and feedbacks between ecological and evolutionary dynamics (eco-evo feedbacks). Due this multi-level nature of interactions, we predict that approaches aimed soley at altering specific species populations in a community (through strain enrichment or inhibition), would only have a transient impact, and species-environment and eco-evo feedbacks would eventually drive the microbial community to its original state. We propose a higher-level engineering approach that is based on thermodynamics of microbial growth, and that considers specifically microbial redox biochemistry. Within this approach the emphasis is on enforcing specific environmental conditions onto the community, that generates higher-level thermodynamic bounds onto the system, which the community structure and function can then adapt to. We believe that the resulting end-state can be ecologically and evolutionarily stable, mimicking the natural states of complex communities. Towards designing the exact nature of the environmental enforcement, thermodynamics and redox biochemistry can act as coarse-grained principles, while the use of electrodes - as electron providing or accepting redox agents - can provide implementation with spatiotemporal control.

Item Type: Journal Article
Subjects: T Technology > TP Chemical technology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Biochemical engineering, Biotechnology
Journal or Publication Title: Current Opinion in Biotechnology
Publisher: Elsevier Ltd.
ISSN: 0958-1669
Official Date: April 2018
Dates:
DateEvent
April 2018Published
4 December 2017Accepted
Volume: 50
Page Range: pp. 121-127
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/K003240/2Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/M017982/1Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268

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