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Context-dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host
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Tavalire, Hannah F., Beechler, Brianna R, Buss, Peter E., Gorsich, Erin E., Hoal, Eileen G., le Roex, Nikki, Spaan, Johannie M., van Helden, Paul D., Ezenwa, Vanessa and Jolles, Anna E. (2018) Context-dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host. Ecology and Evolution, 8 (24). pp. 12712-12726. doi:10.1002/ece3.4699 ISSN 2045-7758.
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Official URL: https://doi.org/10.1002/ece3.4699
Abstract
Disease acts as a powerful driver of evolution in natural host populations, yet individuals in a population often vary in their susceptibility to infection. Energetic trade-offs between immune and reproductive investment lead to the evolution of distinct life history strategies, driven by the relative fitness costs and benefits of resisting infection. However, examples quantifying the cost of resistance outside of the laboratory are rare. Here, we observe two distinct forms of resistance to bovine tuberculosis (bTB), an important zoonotic pathogen, in a free-ranging African buffalo (Syncerus caffer) population. We characterize these phenotypes as “infection resistance,” in which hosts delay or prevent infection, and “proliferation resistance,” in which the host limits the spread of lesions caused by the pathogen after infection has occurred. We found weak evidence that infection resistance to bTB may be heritable in this buffalo population (h2 = 0.10) and comes at the cost of reduced body condition and marginally reduced survival once infected, but also associates with an overall higher reproductive rate. Infection-resistant animals thus appear to follow a “fast” pace-of-life syndrome, in that they reproduce more quickly but die upon infection. In contrast, proliferation resistance had no apparent costs and was associated with measures of positive host health—such as having a higher body condition and reproductive rate. This study quantifies striking phenotypic variation in pathogen resistance and provides evidence for a link between life history variation and a disease resistance trait in a wild mammalian host population.
Item Type: | Journal Article | ||||||||||||||||||||||||
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Subjects: | Q Science > QH Natural history | ||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Tuberculosis in cattle, African buffalo -- Disease resistance, Coevolution, Vector-pathogen relationships | ||||||||||||||||||||||||
Journal or Publication Title: | Ecology and Evolution | ||||||||||||||||||||||||
Publisher: | Wiley-Blackwell Publishing, Inc | ||||||||||||||||||||||||
ISSN: | 2045-7758 | ||||||||||||||||||||||||
Official Date: | December 2018 | ||||||||||||||||||||||||
Dates: |
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Volume: | 8 | ||||||||||||||||||||||||
Number: | 24 | ||||||||||||||||||||||||
Page Range: | pp. 12712-12726 | ||||||||||||||||||||||||
DOI: | 10.1002/ece3.4699 | ||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||
Date of first compliant deposit: | 7 December 2018 | ||||||||||||||||||||||||
Date of first compliant Open Access: | 10 December 2018 | ||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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