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A biphasic model of lifespan in nematode Caenorhabditis elegans worm
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Mulla, Suhayl, Ludlam, Adele R., Elragig, Aiman, Slack, Cathy, Balklava, Zita, Stich, Michael and Cheong, Alex (2023) A biphasic model of lifespan in nematode Caenorhabditis elegans worm. Royal Society Open Science , 10 (2). 220991. doi:10.1098/rsos.220991 ISSN 2054-5703.
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Official URL: http://doi.org/10.1098/rsos.220991
Abstract
Ageing research focuses on identifying lifespan modifiers and understanding and appropriately interpreting their effects. One of the most relevant quantities being studied is the shape of the survival curve that can reveal crucial information on the mechanism of action. Here, we introduce a bilogistic model to describe the shape of the lifespan curves of Caenorhabditis elegans populations. Using the corrected Akaike information criterion and the RMSE as goodness-of-fit tests, we show that the bilogistic model provides a better fit to the experimental data from nematode worms than other mathematical models and can identify and confirm biphasic lifespan data. Our parametric model offers a method to interpret replicate experiments data in terms of the shape parameters of the lifespan curve and enables robust statistical analysis of intra- and inter-group variance. We apply the model to novel lifespan data from C. elegans and Drosophila melanogaster and provide a rational statistical analysis of lifespan modifiers such as temperature and daf-16/FOXO mutation.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QP Physiology | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
Library of Congress Subject Headings (LCSH): | Aging -- Molecular aspects, Caenorhabditis elegans, Drosophila melanogaster, Life spans (Biology), Longevity -- Genetic aspects, Genetics -- Technique | |||||||||
Journal or Publication Title: | Royal Society Open Science | |||||||||
Publisher: | The Royal Society Publishing | |||||||||
ISSN: | 2054-5703 | |||||||||
Official Date: | 23 February 2023 | |||||||||
Dates: |
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Volume: | 10 | |||||||||
Number: | 2 | |||||||||
Article Number: | 220991 | |||||||||
DOI: | 10.1098/rsos.220991 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Copyright Holders: | Ageing research focuses on identifying lifespan modifiers and understanding and appropriately interpreting their effects. One of the most relevant quantities being studied is the shape of the survival curve that can reveal crucial information on the mecha | |||||||||
Date of first compliant deposit: | 18 May 2023 | |||||||||
Date of first compliant Open Access: | 18 May 2023 | |||||||||
RIOXX Funder/Project Grant: |
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