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Tissues as networks of cells : towards generative rules of complex organ development
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Fischer, Sabine C., Bassel, George W. and Kollmannsberger, Philip (2023) Tissues as networks of cells : towards generative rules of complex organ development. Journal of the Royal Society Interface, 20 (204). 20230115. doi:10.1098/rsif.2023.0115 ISSN 1742-5662.
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Official URL: https://doi.org/10.1098/rsif.2023.0115
Abstract
Network analysis is a well-known and powerful tool in molecular biology. More recently, it has been introduced in developmental biology. Tissues can be readily translated into spatial networks such that cells are represented by nodes and intercellular connections by edges. This discretization of cellular organization enables mathematical approaches rooted in network science to be applied towards the understanding of tissue structure and function. Here, we describe how such tissue abstractions can enable the principles that underpin tissue formation and function to be uncovered. We provide an introduction into biologically relevant network measures, then present an overview of different areas of developmental biology where these approaches have been applied. We then summarize the general developmental rules underpinning tissue topology generation. Finally, we discuss how generative models can help to link the developmental rule back to the tissue topologies. Our collection of results points at general mechanisms as to how local developmental rules can give rise to observed topological properties in multicellular systems.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | |||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Developmental biology, Biometry, Bioinformatics -- Research, Cytology, Cells | |||||||||||||||||||||
Journal or Publication Title: | Journal of the Royal Society Interface | |||||||||||||||||||||
Publisher: | The Royal Society | |||||||||||||||||||||
ISSN: | 1742-5662 | |||||||||||||||||||||
Official Date: | 2023 | |||||||||||||||||||||
Dates: |
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Volume: | 20 | |||||||||||||||||||||
Number: | 204 | |||||||||||||||||||||
Article Number: | 20230115 | |||||||||||||||||||||
DOI: | 10.1098/rsif.2023.0115 | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 9 August 2023 | |||||||||||||||||||||
Date of first compliant Open Access: | 9 August 2023 | |||||||||||||||||||||
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