The Library
Data to support "Proline-conditioning and chemically-programmed ice nucleation protects spheroids during cryopreservation"
Tools
Gao, Yanan, Bissoyi, Akalabya, Kinney, Nina L. H., Whale, Thomas F., Guo, Qiongyu and Gibson, Matthew I. (2023) Data to support "Proline-conditioning and chemically-programmed ice nucleation protects spheroids during cryopreservation". [Dataset]
Microsoft Word (Read me file to support dataset)
WRAP_Gibson_178147_Read_Me.rtf - Supplemental Material Available under License Creative Commons Attribution 4.0. Download (452b) |
|
Archive (ZIP) (Dataset file)
WRAP_Gibson_178147_Data.zip - Published Version Available under License Creative Commons Attribution 4.0. Download (23Kb) |
Official URL: https://doi.org/10.1039/D3CC02252H
Abstract
Spheroids mimic 3-D tissue niches better than standard cell cultures. Cryopreserving spheroids, however, remains challenging as conventional cryoprotectants do not mitigate all damage mechanisms. Here chemically-programmed extracellular ice nucleation is used to prevent supercooling, alongside proline pre-conditioning, which are found to synergystically improve post-thaw recovery of spheroids. This validates the need to identify compounds and materials to address both biochemical and biophysical damage pathways beyond standard cryoprotectants.
Item Type: | Dataset | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry | |||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Proline, Nucleation, Ice, Cell aggregation, Cryopreservation of organs, tissues, etc. | |||||||||||||||||||||
Publisher: | University of Warwick, Department of Chemistry | |||||||||||||||||||||
Official Date: | 24 August 2023 | |||||||||||||||||||||
Dates: |
|
|||||||||||||||||||||
Status: | Not Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Media of Output (format): | .xlsx | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Description: | Dataset file to support the article published in Chemical Communications |
|||||||||||||||||||||
Date of first compliant deposit: | 24 August 2023 | |||||||||||||||||||||
Date of first compliant Open Access: | 24 August 2023 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
|
|||||||||||||||||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year