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Unveiling the therapeutic potential of non-coding RNAs in stroke-induced tissue regeneration
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Waseem, Arshi, Khan, Abdul Quaiyoom, Khan, Mohsin Ali, Khan, Rehan, Uddin, Shahab, Boltze, Johannes and Raza, Syed Shadab (2023) Unveiling the therapeutic potential of non-coding RNAs in stroke-induced tissue regeneration. Stem Cells, 41 (11). pp. 987-1005. doi:10.1093/stmcls/sxad062 ISSN 1066-5099.
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WRAP-unveiling-therapeutic-potential-non-coding-RNAs-stroke-induced-tissue-regeneration-2023.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 17 August 2024. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Download (1537Kb) |
Official URL: http://dx.doi.org/10.1093/stmcls/sxad062
Abstract
Stroke is a major contributor to mortality and impairment on a global scale, with few effective treatments available. Aberrant expression of various non-coding RNAs (ncRNAs) has been identified after stroke onset, impacting neurogenesis, angiogenesis, apoptosis and autophagy. The roles and mechanisms of ncRNAs hold great promise for future ischemic stroke treatments, as they could modify stroke impact and course on a well-controllable molecular level. Exploring the functions and underlying mechanisms of ncRNAs after stroke has the potential to unveil novel therapeutic targets for the treatment of stroke and may also pave the way towards novel and more precise diagnostic options for stroke and stroke outcome. This review emphasizes the importance of ncRNAs in the treatment of stroke and their potential as therapeutic targets.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QK Botany Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Library of Congress Subject Headings (LCSH): | Non-coding RNA, MicroRNA, Developmental neurobiology, Blood-vessels—Growth, RNA | ||||||||
Journal or Publication Title: | Stem Cells | ||||||||
Publisher: | Oxford University Press | ||||||||
ISSN: | 1066-5099 | ||||||||
Official Date: | November 2023 | ||||||||
Dates: |
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Volume: | 41 | ||||||||
Number: | 11 | ||||||||
Page Range: | pp. 987-1005 | ||||||||
DOI: | 10.1093/stmcls/sxad062 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Re-use Statement: | This is a pre-copyedited, author-produced version of an article accepted for publication in Stem Cells following peer review. The version of record Arshi Waseem and others, Unveiling the Therapeutic Potential of Non-coding RNAs in Stroke-Induced Tissue Regeneration, Stem Cells, 2023;, sxad062, is available online at: https://doi.org/10.1093/stmcls/sxad062 | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 24 August 2023 |
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