The Library
Optimised Multi-channel Transcranial Direct Current Stimulation (MtDCS) reveals differential involvement of the right-ventrolateral prefrontal cortex (rVLPFC) and insular complex in those predisposed to aberrant experiences
Tools
Joshi, Shalmali, Ruffini, Giulio, Nuttall, Helen E., Watson, Derrick G. and Braithwaite, Jason J. (2024) Optimised Multi-channel Transcranial Direct Current Stimulation (MtDCS) reveals differential involvement of the right-ventrolateral prefrontal cortex (rVLPFC) and insular complex in those predisposed to aberrant experiences. Consciousness and Cognition, 117 . 103610. doi:10.1016/j.concog.2023.103610 ISSN 1053-8100.
|
PDF
1-s2.0-S1053810023001472-main.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (6Mb) | Preview |
|
PDF
WRAP-Optimised-multi-channel-transcranial-direct-current-stimulation-23.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (1765Kb) |
Official URL: https://doi.org/10.1016/j.concog.2023.103610
Abstract
Research has shown a prominent role for cortical hyperexcitability underlying aberrant perceptions, hallucinations, and distortions in human conscious experience – even in neurotypical groups. The rVLPFC has been identified as an important structure in mediating cognitive affective states / feeling conscious states. The current study examined the involvement of the rVLPFC in mediating cognitive affective states in those predisposed to aberrant experiences in the neurotypical population. Participants completed two trait-based measures: (i) the Cortical Hyperexcitability Index_II (CHi_II, a proxy measure of cortical hyperexcitability) and (ii) two factors from the Cambridge Depersonalisation Scale (CDS). An optimised 7-channel MtDCS montage for stimulation conditions (Anodal, Cathodal and Sham) was created targeting the rVLPFC in a single-blind study. At the end of each stimulation session, participants completed a body-threat task (BTAB) while skin conductance responses (SCRs) and psychological responses were recorded. Participants with signs of increasing cortical hyperexcitability showed significant suppression of SCRs in the Cathodal stimulation relative to the Anodal and sSham conditions. Those high on the trait-based measures of depersonalisation-like experiences failed to show reliable effects. Collectively, the findings suggest that baseline brain states can mediate the effects of neurostimulation which would be missed via sample level averaging and without appropriate measures for stratifying individual differences.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QP Physiology |
||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||||||
Library of Congress Subject Headings (LCSH): | Prefrontal cortex, Neurophysiology, Human information processing, Brain stimulation | ||||||||
Journal or Publication Title: | Consciousness and Cognition | ||||||||
Publisher: | Academic Press | ||||||||
ISSN: | 1053-8100 | ||||||||
Official Date: | January 2024 | ||||||||
Dates: |
|
||||||||
Volume: | 117 | ||||||||
Article Number: | 103610 | ||||||||
DOI: | 10.1016/j.concog.2023.103610 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 24 November 2023 | ||||||||
Date of first compliant Open Access: | 15 January 2024 | ||||||||
RIOXX Funder/Project Grant: |
|
||||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year