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High throughput methods to study protein-protein interactions during host-pathogen interactions
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Chandrasekharan, Giridhar and Unnikrishnan, Meera (2024) High throughput methods to study protein-protein interactions during host-pathogen interactions. European Journal of Cell Biology, 103 (2). 151393. doi:10.1016/j.ejcb.2024.151393 ISSN 0171-9335.
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Official URL: http://doi.org/10.1016/j.ejcb.2024.151393
Abstract
The ability of a pathogen to survive and cause an infection is often determined by specific interactions between the host and pathogen proteins. Such interactions can be both intra- and extracellular and may define the outcome of an infection. There are a range of innovative biochemical, biophysical and bioinformatic techniques currently available to identify protein-protein interactions (PPI) between the host and the pathogen. However, the complexity and the diversity of host-pathogen PPIs has led to the development of several high throughput (HT) techniques that enable the study of multiple interactions at once and/or screen multiple samples at the same time, in an unbiased manner. We review here the major HT laboratory-based technologies employed for host-bacterial interaction studies. [Abstract copyright: Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.]
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QP Physiology Q Science > QR Microbiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Proteins -- Analysis, Mass spectrometry -- Research, Protein-protein interactions, Host-parasite relationships -- Genetic aspects, Cytology -- Research | ||||||||
Journal or Publication Title: | European Journal of Cell Biology | ||||||||
Publisher: | Urban und Fischer Verlag | ||||||||
ISSN: | 0171-9335 | ||||||||
Official Date: | June 2024 | ||||||||
Dates: |
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Volume: | 103 | ||||||||
Number: | 2 | ||||||||
Article Number: | 151393 | ||||||||
DOI: | 10.1016/j.ejcb.2024.151393 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Re-use Statement: | ** From PubMed via Jisc Publications Router ** History: received 29-09-2023; revised 18-01-2024; accepted 21-01-2024. | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 5 March 2024 | ||||||||
Date of first compliant Open Access: | 5 March 2024 |
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