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How does airway surface liquid composition vary in different pulmonary diseases, and how can we use this knowledge to model microbial infections?
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Walsh, Dean, Bevan, Jennifer and Harrison, Freya (2024) How does airway surface liquid composition vary in different pulmonary diseases, and how can we use this knowledge to model microbial infections? Microorganisms, 12 (4). 732. doi:10.3390/microorganisms12040732 ISSN 2076-2607.
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Official URL: http://dx.doi.org/10.3390/microorganisms12040732
Abstract
Growth environment greatly alters many facets of pathogen physiology, including pathogenesis and antimicrobial tolerance. The importance of host-mimicking environments for attaining an accurate picture of pathogen behaviour is widely recognised. Whilst this recognition has translated into the extensive development of artificial cystic fibrosis (CF) sputum medium, attempts to mimic the growth environment in other respiratory disease states have been completely neglected. The composition of the airway surface liquid (ASL) in different pulmonary diseases is far less well characterised than CF sputum, making it very difficult for researchers to model these infection environments. In this review, we discuss the components of human ASL, how different lung pathologies affect ASL composition, and how different pathogens interact with these components. This will provide researchers interested in mimicking different respiratory environments with the information necessary to design a host-mimicking medium, allowing for better understanding of how to treat pathogens causing infection in these environments.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QP Physiology | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Library of Congress Subject Headings (LCSH): | Airway (Medicine) -- Pathophysiology, Respiratory mucosa -- Pathophysiology, Pulmonary endothelium, Respiratory organs -- Diseases, Cystic fibrosis, Epithelium | ||||||
Journal or Publication Title: | Microorganisms | ||||||
Publisher: | MDPI | ||||||
ISSN: | 2076-2607 | ||||||
Official Date: | 3 April 2024 | ||||||
Dates: |
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Volume: | 12 | ||||||
Number: | 4 | ||||||
Article Number: | 732 | ||||||
DOI: | 10.3390/microorganisms12040732 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 8 April 2024 | ||||||
Date of first compliant Open Access: | 9 April 2024 | ||||||
RIOXX Funder/Project Grant: |
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