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Evidence for network evolution in an Arabidopsis interactome map
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Arabidopsis Interactome Mapping Consortium (Including:
). (2011) Evidence for network evolution in an Arabidopsis interactome map. Science, Vol.333 (No.6042). pp. 601-607. doi:10.1126/science.1203877 ISSN 0036-8075.Research output not available from this repository.
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Official URL: http://dx.doi.org/10.1126/science.1203877
Abstract
Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QK Botany |
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| Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre | ||||
| Library of Congress Subject Headings (LCSH): | Arabidopsis thaliana, Arabidopsis thaliana -- Genome mapping, Protein-protein interactions, Biological systems, Information theory in biology | ||||
| Journal or Publication Title: | Science | ||||
| Publisher: | American Association for the Advancement of Science | ||||
| ISSN: | 0036-8075 | ||||
| Official Date: | 29 July 2011 | ||||
| Dates: |
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| Volume: | Vol.333 | ||||
| Number: | No.6042 | ||||
| Page Range: | pp. 601-607 | ||||
| DOI: | 10.1126/science.1203877 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | National Science Foundation (U.S.) (NSF), National Human Genome Research Institute (U.S.) (NHGRI), Canada Excellence Research Chairs (CERC), Canadian Institute for Advanced Research (CIAR), James S. McDonnell Foundation (JSMF), Sixth Framework Programme (European Commission) (FP6), National Institute of General Medical Sciences (U.S.) (NIGMS), United States. Agricultural Research Service (ARS), National Institutes of Health (U.S.) (NIH), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||
| Grant number: | 0703905 (NSF), R01HG001715 (NHGRI), 0520253 (NSF), 0313578 (NSF), 220020084 (JSMF), LSHG-CT-2006-037704 (FP6), R01GM066025 (NIGMS), 1907-21000-030 (ARS), F32HG004098 (NIH), F32HG004830 (NIH), F005806 (BBSRC), 0703908 (NSF) |
Data sourced from Thomson Reuters' Web of Knowledge
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