The Library
The role of ERK5 in endothelial cell function
Tools
Nithianandarajah-Jones, Gopika N., Wilm, Bettina, Goldring, Christopher E. P., Müller, Jürgen and Cross, Michael J. (2014) The role of ERK5 in endothelial cell function. Biochemical Society Transactions, 42 (6). pp. 1584-1589. doi:10.1042/BST20140276 ISSN 0300-5127.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1042/BST20140276
Abstract
Extracellular-signal-regulated kinase 5 (ERK5), also termed big MAPK1 (BMK1), is the most recently
discovered member of the mitogen-activated protein kinase (MAPK) family. It is expressed in a variety
of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of
Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development
and vascular integrity. In vitro studies have revealed that, in endothelial cells, ERK5 is required for preventing
apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses
on our current understanding of the role of ERK5 in regulating endothelial cell function.
Item Type: | Journal Article | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QP Physiology | ||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||||||
Library of Congress Subject Headings (LCSH): | Mitogen-activated protein kinases, Atherosclerosis, Neovascularization, Blood-vessels -- Growth -- Molecular aspects, Endothelium | ||||||||||||
Journal or Publication Title: | Biochemical Society Transactions | ||||||||||||
Publisher: | Portland Press Ltd | ||||||||||||
ISSN: | 0300-5127 | ||||||||||||
Official Date: | December 2014 | ||||||||||||
Dates: |
|
||||||||||||
Volume: | 42 | ||||||||||||
Number: | 6 | ||||||||||||
Page Range: | pp. 1584-1589 | ||||||||||||
DOI: | 10.1042/BST20140276 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
RIOXX Funder/Project Grant: |
|
||||||||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |