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Optimal viral strategies for bypassing RNA silencing
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Rodrigo, G., Carrera, J., Jaramillo, Alfonso and Elena, S. F. (2010) Optimal viral strategies for bypassing RNA silencing. Journal of The Royal Society Interface, 8 (55). pp. 257-268. doi:10.1098/rsif.2010.0264 ISSN 1742-5689.
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Official URL: http://dx.doi.org/10.1098/rsif.2010.0264
Abstract
The RNA silencing pathway constitutes a defence mechanism highly conserved in eukaryotes, especially in plants, where the underlying working principle relies on the repressive action triggered by the intracellular presence of double-stranded RNAs. This immune system performs a post-transcriptional suppression of aberrant mRNAs or viral RNAs by small interfering RNAs (siRNAs) that are directed towards their target in a sequence-specific manner. However, viruses have evolved strategies to escape from silencing surveillance while promoting their own replication. Several viruses encode suppressor proteins that interact with different elements of the RNA silencing pathway and block it. The different suppressors are not phylogenetically nor structurally related and also differ in their mechanism of action. Here, we adopt a model-driven forward-engineering approach to understand the evolution of suppressor proteins and, in particular, why viral suppressors preferentially target some components of the silencing pathway. We analysed three strategies characterized by different design principles: replication in the absence of a suppressor, suppressors targeting the first protein component of the pathway and suppressors targeting the siRNAs. Our results shed light on the question of whether a virus must opt for devoting more time into transcription or into translation and on which would be the optimal step of the silencing pathway to be targeted by suppressors. In addition, we discussed the evolutionary implications of such designing principles.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Library of Congress Subject Headings (LCSH): | RNA, RNA interference | ||||
| Journal or Publication Title: | Journal of The Royal Society Interface | ||||
| Publisher: | The Royal Society Publishing | ||||
| ISSN: | 1742-5689 | ||||
| Official Date: | 23 December 2010 | ||||
| Dates: |
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| Volume: | 8 | ||||
| Number: | 55 | ||||
| Number of Pages: | 12 | ||||
| Page Range: | pp. 257-268 | ||||
| DOI: | 10.1098/rsif.2010.0264 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Spain. Ministerio de Ciencia e Innovación (MICINN), Sixth Framework Programme (European Commission) (FP6), Seventh Framework Programme (European Commission) (FP7), European Regional Development Fund (ERDF), Fondation pour la recherche médicale (FRM), HPC-Europa programme, Spain. Generalitat Valenciana [Valencian Government], European Molecular Biology Organization (EMBO), Santa Fe Institute (Santa Fe, N.M.) | ||||
| Grant number: | BFU2009-06993 (MICINN), TIN-2006-12860 (MICCIN), NEST-043340 (FP6), ICT-043338 (FP7), KBBE-212894 (FP7),RII3-CT-2003-506079 (HPC-Europa) |
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