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Core steps of membrane-bound peptidoglycan biosynthesis : recent advances, insight and opportunities
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Teo, Alvin and Roper, David I. (2015) Core steps of membrane-bound peptidoglycan biosynthesis : recent advances, insight and opportunities. Antibiotics, 4 (4). pp. 495-520. doi:10.3390/antibiotics4040495 ISSN 2079-6382.
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Official URL: http://dx.doi.org/10.3390/antibiotics4040495
Abstract
We are entering an era where the efficacy of current antibiotics is declining, due to the development and widespread dispersion of antibiotic resistance mechanisms. These factors highlight the need for novel antimicrobial discovery. A large number of antimicrobial natural products elicit their effect by directly targeting discrete areas of peptidoglycan metabolism. Many such natural products bind directly to the essential cell wall precursor Lipid II and its metabolites, i.e., preventing the utlisation of vital substrates by direct binding rather than inhibiting the metabolising enzymes themselves. Concurrently, there has been an increase in the knowledge surrounding the proteins essential to the metabolism of Lipid II at and across the cytoplasmic membrane. In this review, we draw these elements together and look to future antimicrobial opportunities in this area.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Peptidoglycans, Drug resistance in microorganisms, Anti-infective agents | ||||||||
| Journal or Publication Title: | Antibiotics | ||||||||
| Publisher: | M.D.P.I.AG | ||||||||
| ISSN: | 2079-6382 | ||||||||
| Official Date: | 3 November 2015 | ||||||||
| Dates: |
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| Volume: | 4 | ||||||||
| Number: | 4 | ||||||||
| Number of Pages: | 26 | ||||||||
| Page Range: | pp. 495-520 | ||||||||
| DOI: | 10.3390/antibiotics4040495 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 31 March 2016 | ||||||||
| Date of first compliant Open Access: | 31 March 2016 | ||||||||
| Funder: | European Union (EU), Marie Skłodowska-Curie actions, Seventh Framework Programme (European Commission) (FP7), Medical Research Council (Great Britain) (MRC) | ||||||||
| Grant number: | 316630 (FP7), G1100127 (MRC), G1001023 (MRC) |
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