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Core steps of membrane-bound peptidoglycan biosynthesis : recent advances, insight and opportunities

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Teo, Alvin and Roper, David I. (2015) Core steps of membrane-bound peptidoglycan biosynthesis : recent advances, insight and opportunities. Antibiotics, 4 (4). pp. 495-520. doi:10.3390/antibiotics4040495 ISSN 2079-6382.

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Official URL: http://dx.doi.org/10.3390/antibiotics4040495

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Abstract

We are entering an era where the efficacy of current antibiotics is declining, due to the development and widespread dispersion of antibiotic resistance mechanisms. These factors highlight the need for novel antimicrobial discovery. A large number of antimicrobial natural products elicit their effect by directly targeting discrete areas of peptidoglycan metabolism. Many such natural products bind directly to the essential cell wall precursor Lipid II and its metabolites, i.e., preventing the utlisation of vital substrates by direct binding rather than inhibiting the metabolising enzymes themselves. Concurrently, there has been an increase in the knowledge surrounding the proteins essential to the metabolism of Lipid II at and across the cytoplasmic membrane. In this review, we draw these elements together and look to future antimicrobial opportunities in this area.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Peptidoglycans, Drug resistance in microorganisms, Anti-infective agents
Journal or Publication Title: Antibiotics
Publisher: M.D.P.I.AG
ISSN: 2079-6382
Official Date: 3 November 2015
Dates:
DateEvent
3 November 2015Published
26 October 2015Accepted
30 July 2015Submitted
Volume: 4
Number: 4
Number of Pages: 26
Page Range: pp. 495-520
DOI: 10.3390/antibiotics4040495
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 31 March 2016
Date of first compliant Open Access: 31 March 2016
Funder: European Union (EU), Marie Skłodowska-Curie actions, Seventh Framework Programme (European Commission) (FP7), Medical Research Council (Great Britain) (MRC)
Grant number: 316630 (FP7), G1100127 (MRC), G1001023 (MRC)

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