Poon, Cheuk Ka, Tang, Owen, Chen, Xin-Ming, Pham, Binh T. T., Gody, Guillaume, Pollock, Carol A., Hawkett, Brian S. and Perrier, Sébastien (2016) Preparation of inert polystyrene latex particles as microRNA delivery vectors by surfactant-free RAFT emulsion polymerization. Biomacromolecules, 17 (3). pp. 965-973. doi:10.1021/acs.biomac.5b01633 ISSN 1525-7797.
![[thumbnail of WRAP_1274179-ch-121116-np_mirna_complexes_revised.pdf]](https://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
WRAP_1274179-ch-121116-np_mirna_complexes_revised.pdf - Accepted Version - Requires a PDF viewer. Download (1MB) |
Abstract
We present the preparation of 11 nm polyacrylamide-stabilized polystyrene latex particles for conjugation to a microRNA model by surfactant-free RAFT emulsion polymerization. Our synthetic strategy involved the preparation of amphiphilic polyacrylamide-block-polystyrene copolymers, which were able to self-assemble into polymeric micelles and “grow” into polystyrene latex particles. The surface of these sterically stabilized particles was postmodified with a disulfide-bearing linker for the attachment of the microRNA model, which can be released from the latex particles under reducing conditions. These nanoparticles offer the advantage of ease of preparation via a scaleable process, and the versatility of their synthesis makes them adaptable to a range of applications.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Polystyrene, Latex, Addition polymerization, Block copolymers, Fragmentation reactions |
| Journal or Publication Title: | Biomacromolecules |
| Publisher: | American Chemical Society |
| ISSN: | 1525-7797 |
| Official Date: | 25 January 2016 |
| Dates: | Date Event 25 January 2016 Published 22 January 2016 Modified 4 December 2015 Submitted |
| Volume: | 17 |
| Number: | 3 |
| Page Range: | pp. 965-973 |
| DOI: | 10.1021/acs.biomac.5b01633 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Date of first compliant deposit: | 15 November 2016 |
| Date of first compliant Open Access: | 25 January 2017 |
| Funder: | University of Sydney, Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), Monash-Warwick Alliance |
| Grant number: | WM130055 (RSWRMA) |
| URI: | https://wrap.warwick.ac.uk/83846/ |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |