Boltze, Johannes, Didwischus, Nadine, Merrow, Martha, Dallmann, Robert and Plesnila, N. (2021) Circadian effects on stroke outcome – did we not wake up in time for neuroprotection? Journal of Cerebral Blood Flow & Metabolism, 41 (3). pp. 684-686. doi:10.1177/0271678X20978711 ISSN 0271-678X.
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Abstract
The occurrence of stroke in humans peaks in the morning. A recent study revealed that time of day mitigates the therapeutic impact of neuroprotective paradigms. These findings might not only explain the previous failure of translation of neuroprotective therapies but inspire new paradigms in stroke chronopathophysiology research. Taking chronotype into account may complement the many factors that influence efficacy of experimental therapies in stroke.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Cerebrovascular disease, Chronobiology, Circadian rhythms -- Health aspects -- Research |
| Journal or Publication Title: | Journal of Cerebral Blood Flow & Metabolism |
| Publisher: | Sage Publications Ltd. |
| ISSN: | 0271-678X |
| Official Date: | 1 March 2021 |
| Dates: | Date Event 1 March 2021 Published 18 December 2020 Available 25 September 2020 Accepted |
| Volume: | 41 |
| Number: | 3 |
| Page Range: | pp. 684-686 |
| DOI: | 10.1177/0271678X20978711 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 2 October 2020 |
| Date of first compliant Open Access: | 2 October 2020 |
| Related URLs: | |
| URI: | https://wrap.warwick.ac.uk/142467/ |
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