(2014) Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors. Molecular Cell, Volume 53 (Number 3). pp. 369-379. doi:10.1016/j.molcel.2013.12.020 ISSN 1097-2765.
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Abstract
Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses. Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-specific transcriptional regulators, the group VII ethylene response factors (ERFs). We show that the N-end rule pathway of targeted proteolysis targets these proteins for destruction in the presence of NO, and we establish them as critical regulators of diverse NO-regulated processes, including seed germination, stomatal closure, and hypocotyl elongation. Furthermore, we define the molecular mechanism for NO control of germination and crosstalk with abscisic acid (ABA) signaling through ERF-regulated expression of ABSCISIC ACID INSENSITIVE5 (ABI5). Our work demonstrates how NO sensing is integrated across multiple physiological processes by direct modulation of transcription factor stability and identifies group VII ERFs as central hubs for the perception of gaseous signals in plants.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
| Library of Congress Subject Headings (LCSH): | Nitric oxide , Prokaryotes , Eukaryotic cells |
| Journal or Publication Title: | Molecular Cell |
| Publisher: | Cell Press |
| ISSN: | 1097-2765 |
| Official Date: | 6 February 2014 |
| Dates: | Date Event 6 February 2014 Published 13 December 2013 Accepted 4 October 2013 Submitted |
| Volume: | Volume 53 |
| Number: | Number 3 |
| Page Range: | pp. 369-379 |
| DOI: | 10.1016/j.molcel.2013.12.020 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 26 December 2015 |
| Date of first compliant Open Access: | 26 December 2015 |
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), SABMiller (Firm), Malaysia, University of Nottingham, University of Sheffield , Spain. Cortes Generales, Marie Curie International Incoming Fellowship (IIF), Fonds zur Förderung der Wissenschaftlichen Forschung (Austria), Spain. Ministerio de Ciencia e Innovación (MICINN) |
| Grant number: | BB/G02488X/1, BB/G010595/1, BB/F006934/1, BB/K000144/1, BB/K000063/1, BB/G015066/1 (BBSRC) ; CSD2007-00057 and BIO2011-27526 (SCG) ; P21215, P25488 (FWF) ; BIO2010-15071 (MICINN) |
| URI: | https://wrap.warwick.ac.uk/59286/ |
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