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Role for astroglia-derived BDNF and MSK1 in homeostatic synaptic plasticity
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Lalo, Ulyana, Bogdanov, Alexander, Moss, Guy W. J., Frenguelli, Bruno G. and Pankratov, Yuriy (2018) Role for astroglia-derived BDNF and MSK1 in homeostatic synaptic plasticity. Neuroglia, 1 (2). pp. 381-394. doi:10.3390/neuroglia1020026
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WRAP-role-astroglia-derived-BDNF-MSK1-homeostatic-synaptic-plasticity-Frenguelli-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (3353Kb) | Preview |
Official URL: http://dx.doi.org/10.3390/neuroglia1020026
Abstract
Homeostatic scaling of synaptic strength in response to environmental stimuli may underlie the beneficial effects of an active lifestyle on brain function. Our previous results highlighted a key role for brain-derived neurotrophic factor (BDNF) and mitogen- and stress-activated protein kinase 1 (MSK1) in experience-related homeostatic synaptic plasticity. Astroglia have recently been shown to serve as an important source of BDNF. To elucidate a role for astroglia-derived BDNF, we explored homeostatic synaptic plasticity in transgenic mice with an impairment in the BDNF/MSK1 pathway (MSK1 kinase dead knock-in (KD) mice) and impairment of glial exocytosis (dnSNARE mice). We observed that prolonged tonic activation of astrocytes caused BDNF-dependent upregulation of excitatory synaptic currents accompanied by enlargement of synaptic boutons. We found that exposure to environmental enrichment (EE) and caloric restriction (CR) strongly upregulated excitatory but downregulated inhibitory synaptic currents in old wild-type mice, thus counterbalancing the impact of ageing on synaptic transmission. In parallel, EE and CR enhanced astrocytic Ca2+-signalling. Importantly, we observed a significant deficit in the effects of EE and CR on synaptic transmission in the MSK1 KD and dnSNARE mice. Combined, our results strongly support the importance of astrocytic exocytosis of BDNF for the beneficial effects of EE and CR on synaptic transmission and plasticity in the ageing brain.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QP Physiology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Aging, Dendrites, Neuroplasticity, GABA, GABA -- Receptors, Neural transmission, Field ion microscopy | ||||||||||||
| Journal or Publication Title: | Neuroglia | ||||||||||||
| Publisher: | MDPI | ||||||||||||
| ISSN: | 2571-6980 | ||||||||||||
| Official Date: | 22 November 2018 | ||||||||||||
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| Date of first compliant deposit: | 5 September 2019 | ||||||||||||
| Volume: | 1 | ||||||||||||
| Number: | 2 | ||||||||||||
| Page Range: | pp. 381-394 | ||||||||||||
| DOI: | 10.3390/neuroglia1020026 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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