Shah, Poonam, Chaumet, Alexandre, Royle, Stephen J. and Bard, Frederic A. (2019) The NAE Pathway : autobahn to the nucleus for cell surface receptors. Cells, 8 (8). 915. doi:10.3390/cells8080915 ISSN 2073-4409.
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Abstract
Various growth factors and full-length cell surface receptors such as EGFR are translocated from the cell surface to the nucleoplasm, baffling cell biologists to the mechanisms and functions of this process. Elevated levels of nuclear EGFR correlate with poor prognosis in various cancers. In recent years, nuclear EGFR has been implicated in regulating gene transcription, cell proliferation and DNA damage repair. Different models have been proposed to explain how the receptors are transported into the nucleus. However, a clear consensus has yet to be reached. Recently, we described the nuclear envelope associated endosomes (NAE) pathway, which delivers EGFR from the cell surface to the nucleus. This pathway involves transport, docking and fusion of NAEs with the outer membrane of the nuclear envelope. EGFR is then presumed to be transported through the nuclear pore complex, extracted from membranes and solubilised. The SUN1/2 nuclear envelope proteins, Importin-beta, nuclear pore complex proteins and the Sec61 translocon have been implicated in the process. While this framework can explain the cell surface to nucleus traffic of EGFR and other cell surface receptors, it raises several questions that we consider in this review, together with implications for health and disease.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history Q Science > QP Physiology |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| SWORD Depositor: | Library Publications Router |
| Library of Congress Subject Headings (LCSH): | Epidermal growth factor -- Receptors, Endosomes, Insulin -- Receptors , Nuclear membranes |
| Journal or Publication Title: | Cells |
| Publisher: | MDPI AG |
| ISSN: | 2073-4409 |
| Official Date: | 16 August 2019 |
| Dates: | Date Event 16 August 2019 Published 13 August 2019 Accepted |
| Volume: | 8 |
| Number: | 8 |
| Article Number: | 915 |
| DOI: | 10.3390/cells8080915 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 17 December 2019 |
| Date of first compliant Open Access: | 17 December 2019 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID |
| Related URLs: | |
| URI: | https://wrap.warwick.ac.uk/125854/ |
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