The Library
Inflammatory signaling and brown fat activity
Tools
Tools
Tools
Omran, Farah and Christian, Mark (2020) Inflammatory signaling and brown fat activity. Frontiers in Endocrinology, 11 . doi:10.3389/fendo.2020.00156 ISSN 1664-2392.
|
PDF
WRAP-inflammatory-signaling-brown-fat-activity-Christian-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (868Kb) | Preview |
Official URL: http://dx.doi.org/10.3389/fendo.2020.00156
Abstract
Obesity is characterized by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory cytokines. In comparison to WAT, relatively little is known about the inflammatory status of brown adipose tissue (BAT) in physiology and pathophysiology. Because BAT and brown/beige adipocytes are specialized in energy expenditure they have protective roles against obesity and associated metabolic diseases. BAT appears to be is less susceptible to developing inflammation than WAT. However, there is increasing evidence that inflammation directly alters the thermogenic activity of brown fat by impairing its capacity for energy expenditure and glucose uptake. The inflammatory microenvironment can be affected by cytokines secreted by immune cells as well as by the brown adipocytes themselves. Therefore, pro-inflammatory signals represent an important component of the thermogenic potential of brown and beige adipocytes and may contribute their dysfunction in obesity.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QM Human anatomy Q Science > QP Physiology Q Science > QR Microbiology R Medicine > RB Pathology R Medicine > RM Therapeutics. Pharmacology |
||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||
| Library of Congress Subject Headings (LCSH): | Inflammation, Brown adipose tissue, Cytokines, Fat cells, Adipose tissues | ||||||
| Journal or Publication Title: | Frontiers in Endocrinology | ||||||
| Publisher: | Frontiers Media | ||||||
| ISSN: | 1664-2392 | ||||||
| Official Date: | 24 March 2020 | ||||||
| Dates: |
|
||||||
| Volume: | 11 | ||||||
| DOI: | 10.3389/fendo.2020.00156 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 26 March 2020 | ||||||
| Date of first compliant Open Access: | 26 March 2020 | ||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
