Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Ribosome biogenesis serves as a therapeutic target for treating endometriosis and the associated complications

Tools
- Tools
+ Tools

Chang, Cherry Yin-Yi, Chiang, An-Jen, Yan, Man-Ju, Lai, Ming-Tsung, Su, Yun-Yi, Huang, Hsin-Yi, Chang, Chan-Yu, Li, Ya-Hui, Li, Pei-Fen, Chen, Chih-Mei, Hwang, Tritium, Hogg, Chloe, Greaves, Erin and Sheu, Jim Jinn-Chyuan (2022) Ribosome biogenesis serves as a therapeutic target for treating endometriosis and the associated complications. Biomedicines, 10 (1). e185. doi:10.3390/biomedicines10010185

[img]
Preview
PDF
WRAP-Ribosome-biogenesis-serves-therapeutic-target-treating-endometriosis-associated-complications-Greaves-2022.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (3375Kb) | Preview
Official URL: https://doi.org/10.3390/biomedicines10010185

Request Changes to record.

Abstract

Ribosome biogenesis is a cellular process critical for protein homeostasis during cell growth and multiplication. Our previous study confirmed up-regulation of ribosome biogenesis during endometriosis progression and malignant transition, thus anti-ribosome biogenesis may be effective for treating endometriosis and the associated complications. A mouse model with human endometriosis features was established and treated with three different drugs that can block ribosome biogenesis, including inhibitors against mTOR/PI3K (GSK2126458) and RNA polymerase I (CX5461 and BMH21). The average lesion numbers and disease frequencies were significantly reduced in treated mice as compared to controls treated with vehicle. Flow cytometry analyses confirmed the reduction of small peritoneal macrophage and neutrophil populations with increased large versus small macrophage ratios, suggesting inflammation suppression by drug treatments. Lesions in treated mice also showed lower nerve fiber density which can support the finding of pain-relief by behavioral studies. Our study therefore suggested ribosome biogenesis as a potential therapeutic target for treating endometriosis.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QP Physiology
R Medicine > RB Pathology
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Endometriosis , Endometriosis -- Treatment , Ribosomes , RNA polymerases , Inflammation , Homeostasis
Journal or Publication Title: Biomedicines
Publisher: MDPI
ISSN: 2227-9059
Official Date: 17 January 2022
Dates:
DateEvent
17 January 2022Published
13 January 2022Accepted
Volume: 10
Number: 1
Article Number: e185
DOI: 10.3390/biomedicines10010185
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
107-2911-I-110-505Ministry of Science and Technology, Taiwanhttp://dx.doi.org/10.13039/501100004663
108-2911-I-110-501Ministry of Science and Technology, Taiwanhttp://dx.doi.org/10.13039/501100004663
107-2912-I-110-510Ministry of Science and Technology, Taiwanhttp://dx.doi.org/10.13039/501100004663
DMR108-078China Medical University Hospitalhttp://dx.doi.org/10.13039/501100004391
M.R./M009238/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
M.R./S002456/2[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
Studentship[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us