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SKN-1/NRF2 up-regulation by vitamin A is conserved from nematodes to mammals and is critical for lifespan extension in Caenorhabditis elegans
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Sirakawin, Chaweewan, Lin, Dongfa, Zhou, Ziyue, Xiaoxin, Wang, Kelleher, Rhianne, Huang, Shangyuan, Long, Weimiao, Pires-da Silva, André Francisco, Liu, Yu, Wang, Jingjing and Vinnikov, Ilya A. (2024) SKN-1/NRF2 up-regulation by vitamin A is conserved from nematodes to mammals and is critical for lifespan extension in Caenorhabditis elegans. Aging Cell, 23 (3). e14064. doi:10.1111/acel.14064 ISSN 1474-9726.
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WRAP-SKN-1-NRF2-up-regulation-vitamin-A-conserved-nematodes1-23.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (2043Kb) |
Official URL: https://doi.org/10.1111/acel.14064
Abstract
Vitamin A (VA) is a micronutrient essential for the physiology of many organisms, but its role in longevity and age-related diseases remains unclear. In this work, we used Caenorhabditis elegans to study the impact of various bioactive compounds on lifespan. We demonstrate that VA extends lifespan and reduces lipofuscin and fat accumulation while increasing resistance to heat and oxidative stress. This resistance can be attributed to high levels of detoxifying enzymes called glutathione S-transferases, induced by the transcription factor skinhead-1 (SKN-1). Notably, VA upregulated the transcript levels of skn-1 or its mammalian ortholog NRF2 in both C. elegans, human cells, and liver tissues of mice. Moreover, the loss-of-function genetic models demonstrated a critical involvement of the SKN-1 pathway in longevity extension by VA. Our study thus provides novel insights into the molecular mechanism of anti-aging and anti-oxidative effects of VA, suggesting that this micronutrient could be used for the prevention and/or treatment of age-related disorders.
Item Type: | Journal Article | |||||||||||||||
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Alternative Title: | ||||||||||||||||
Subjects: | Q Science > QH Natural history Q Science > QL Zoology Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Caenorhabditis elegans , Aging, Vitamin A , Nematodes | |||||||||||||||
Journal or Publication Title: | Aging Cell | |||||||||||||||
Publisher: | Wiley-Blackwell Publishing Ltd. | |||||||||||||||
ISSN: | 1474-9726 | |||||||||||||||
Official Date: | March 2024 | |||||||||||||||
Dates: |
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Volume: | 23 | |||||||||||||||
Number: | 3 | |||||||||||||||
Article Number: | e14064 | |||||||||||||||
DOI: | 10.1111/acel.14064 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Copyright Holders: | © 2023 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. | |||||||||||||||
Date of first compliant deposit: | 12 December 2023 | |||||||||||||||
Date of first compliant Open Access: | 17 January 2024 | |||||||||||||||
RIOXX Funder/Project Grant: |
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