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The endometrial microbiota and early pregnancy loss
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Odendaal, Joshua, Black, Naomi, Bennett, Phillip R., Brosens, Jan J., Quenby, Siobhan and MacIntyre, David A. (2024) The endometrial microbiota and early pregnancy loss. Human Reproduction, 39 (4). pp. 638-646. doi:10.1093/humrep/dead274 ISSN 1460-2350.
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Official URL: https://doi.org/10.1093/humrep/dead274
Abstract
The human endometrium is a dynamic entity that plays a pivotal role in mediating the complex interplay between the mother and developing embryo. Endometrial disruption can lead to pregnancy loss, impacting both maternal physical and psychological health. Recent research suggests that the endometrial microbiota may play a role in this, although the exact mechanisms are still being explored, aided by recent technological advancements and our growing understanding of host immune responses. Suboptimal or dysbiotic vaginal microbiota, characterized by increased microbial diversity and reduced Lactobacillus dominance, has been associated with various adverse reproductive events, including miscarriage. However, the mechanisms linking the lower reproductive tract microbiota with pregnancy loss remain unclear. Recent observational studies implicate a potential microbial continuum between the vaginal and endometrial niche in patients with pregnancy loss; however, transcervical sampling of the low biomass endometrium is highly prone to cross-contamination, which is often not controlled for. In this review, we explore emerging evidence supporting the theory that a dysbiotic endometrial microbiota may modulate key inflammatory pathways required for successful embryo implantation and pregnancy development. We also highlight that a greater understanding of the endometrial microbiota, its relationship with the local endometrial microenvironment, and potential interventions remain a focus for future research.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QH Natural history Q Science > QM Human anatomy Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Endometrium , Endometriosis, Miscarriage , Pregnancy -- Complications, Microbiomes | ||||||||
Journal or Publication Title: | Human Reproduction | ||||||||
Publisher: | Oxford University Press (OUP) | ||||||||
ISSN: | 1460-2350 | ||||||||
Official Date: | April 2024 | ||||||||
Dates: |
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Volume: | 39 | ||||||||
Number: | 4 | ||||||||
Page Range: | pp. 638-646 | ||||||||
DOI: | 10.1093/humrep/dead274 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 19 February 2024 | ||||||||
Date of first compliant Open Access: | 19 February 2024 | ||||||||
RIOXX Funder/Project Grant: |
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