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Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection
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Taylor, Lewis, Von Lendenfeld, Felix, Ashton, Anna, Sanghani, Harshmeena, Di Pretoro, Simona, Usselmann, Laura Emma Jane, Veretennikova, Maria, Dallmann, Robert, McKeating, Jane A., Vasudevan, Sridhar R. and Jagannath, Aarti (2023) Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection. iScience, 26 (2). 105877. doi:10.1016/j.isci.2022.105877 ISSN 2589-0042.
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Official URL: https://doi.org/10.1016/j.isci.2022.105877
Abstract
Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. However, the mechanism(s) underpinning higher rates of respiratory viral infection following SCRD remain poorly characterised. To address this, we investigated the effects of acute sleep deprivation on the mouse lung transcriptome. Here we show that sleep deprivation profoundly alters the transcriptional landscape of the lung, causing the suppression of both innate and adaptive immune systems, disrupting the circadian clock, and activating genes implicated in SARS-CoV-2 replication, thereby generating a lung environment that could promote viral infection and associated disease pathogenesis. Our study provides a mechanistic explanation of how SCRD increases the risk of respiratory viral infections including SARS-CoV-2 and highlights possible therapeutic avenues for the prevention and treatment of respiratory viral infection.
| Item Type: | Journal Article | ||||||||||||||||||||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Circadian rhythms, Circadian rhythms -- Health aspects , Sleep deprivation , Sleep deprivation -- Health aspects, Respiratory infections, Respiratory organs -- Diseases, Respiratory infections -- Treatment | ||||||||||||||||||||||||
| Journal or Publication Title: | iScience | ||||||||||||||||||||||||
| Publisher: | Cell Press | ||||||||||||||||||||||||
| ISSN: | 2589-0042 | ||||||||||||||||||||||||
| Official Date: | 17 February 2023 | ||||||||||||||||||||||||
| Dates: |
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| Volume: | 26 | ||||||||||||||||||||||||
| Number: | 2 | ||||||||||||||||||||||||
| Article Number: | 105877 | ||||||||||||||||||||||||
| DOI: | 10.1016/j.isci.2022.105877 | ||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||
| Date of first compliant deposit: | 3 January 2023 | ||||||||||||||||||||||||
| Date of first compliant Open Access: | 3 January 2023 | ||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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