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A tell tail sign : a conserved C-terminal tail-anchor domain targets a subset of pathogen effectors to the plant endoplasmic reticulum
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Breeze, Emily, Vale, Victoria, McLellan, Hazel, Pecrix, Yann, Godiard, Laurence, Grant, Murray and Frigerio, Lorenzo (2023) A tell tail sign : a conserved C-terminal tail-anchor domain targets a subset of pathogen effectors to the plant endoplasmic reticulum. Journal of Experimental Botany, 74 (10). pp. 3188-3202. doi:10.1093/jxb/erad075 ISSN 1460-2431.
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Official URL: https://doi.org/10.1093/jxb/erad075
Abstract
The endoplasmic reticulum (ER) is the entry point to the secretory pathway and, as such, is critical for adaptive responses to biotic stress, when the demand for de novo synthesis of immunity-related proteins and signalling components increases significantly. Successful phytopathogens have evolved an arsenal of small effector proteins which collectively reconfigure multiple host components and signalling pathways to promote virulence; a small, but important, subset of which are targeted to the endomembrane system including the ER. We identified and validated a conserved C-terminal tail-anchor motif in a set of pathogen effectors known to localize to the ER from the oomycetes Hyaloperonospora arabidopsidis and Plasmopara halstedii (downy mildew of Arabidopsis and sunflower, respectively) and used this protein topology to develop a bioinformatic pipeline to identify putative ER-localized effectors within the effectorome of the related oomycete, Phytophthora infestans, the causal agent of potato late blight. Many of the identified P. infestans tail-anchor effectors converged on ER-localized NAC transcription factors, indicating that this family is a critical host target for multiple pathogens.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QK Botany Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Endoplasmic reticulum, Cell organelles, Oomycetes, Transcription factors, Phytophthora infestans | |||||||||
| Journal or Publication Title: | Journal of Experimental Botany | |||||||||
| Publisher: | Oxford University Press (OUP) | |||||||||
| ISSN: | 1460-2431 | |||||||||
| Official Date: | 19 May 2023 | |||||||||
| Dates: |
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| Volume: | 74 | |||||||||
| Number: | 10 | |||||||||
| Page Range: | pp. 3188-3202 | |||||||||
| DOI: | 10.1093/jxb/erad075 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 28 June 2023 | |||||||||
| Date of first compliant Open Access: | 28 June 2023 | |||||||||
| RIOXX Funder/Project Grant: |
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