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Degradable glycopolymers for saRNA transfection
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Monaco, Alessandra, Barbieri, Beatriz Dias, Yilmaz, Gokhan, Shattock, Robin J. and Becer, C. Remzi (2023) Degradable glycopolymers for saRNA transfection. Polymer Chemistry, 14 (22). pp. 2750-2761. doi:10.1039/d3py00260h ISSN 1759-9954.
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WRAP-degradable-glycopolymers- saRNA-transfection-Becer-2023.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial. Download (2379Kb) | Preview |
Official URL: https://doi.org/10.1039/d3py00260h
Abstract
Gene delivery is a powerful technique that is often exploited in the treatment of several diseases. Currently, most gene vectors are expensive virus-based systems, which can trigger immune responses. As a cheaper and safer alternative to these systems, biodegradable polymers have been widely used to develop gene delivery systems due to their different desirable characteristics. In particular, poly(amido amine)s possess critical desirable characteristics, such as high cell transfection activity, that make them suitable and efficient for gene delivery. In this study, reducible poly(amido amine)s with different side chain lengths and glycopolymers have been developed to create polyplexes with self-amplifying RNA (saRNA). The cell transfection assay showed that sugar decorated poly(amido amine)s revealed better saRNA transfection activity than other non-decorated poly(amido amine)s. Nevertheless, no differences were obtained between the poly(amido amine)s with different side chain lengths. Overall, biodegradable poly(amido amine)s with different alcohols and sugars have been synthesized with high molecular weights and low molecular weight distributions to develop an optimal saRNA delivery system.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Polymers -- Synthesis, RNA, RNA editing, Gene therapy, Biomedical materials, Polymerization | ||||||||
Journal or Publication Title: | Polymer Chemistry | ||||||||
Publisher: | Royal Society of Chemistry | ||||||||
ISSN: | 1759-9954 | ||||||||
Official Date: | 14 June 2023 | ||||||||
Dates: |
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Volume: | 14 | ||||||||
Number: | 22 | ||||||||
Page Range: | pp. 2750-2761 | ||||||||
DOI: | 10.1039/d3py00260h | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 26 July 2023 | ||||||||
Date of first compliant Open Access: | 26 July 2023 | ||||||||
RIOXX Funder/Project Grant: |
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